Sigma-Aldrich recommends that solutions be prepared fresh and not stored. Solutions "are stable only for a few hours and cannot be kept overnight." See: Sigma-Aldrich Handbook of Dyes, Stains, and Indicators, Green, F. ed., p. 407.
I2633
Cardiogreen
Powder
Synonym(s):
Foxgreen, IC Green, Indocyanine green
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25 MG
€103.00
50 MG
€189.00
100 MG
€275.00
About This Item
Empirical Formula (Hill Notation):
C43H47N2NaO6S2
CAS Number:
Molecular Weight:
774.96
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
222-751-5
MDL number:
Beilstein/REAXYS Number:
4115884
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Product Name
Cardiogreen, polymethine dye
InChI key
MOFVSTNWEDAEEK-UHFFFAOYSA-M
InChI
1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1
SMILES string
[Na+].CC1(C)/C(=C\C=C\C=C\C=C\C2=[N+](CCCCS([O-])(=O)=O)c3ccc4ccccc4c3C2(C)C)N(CCCCS([O-])(=O)=O)c5ccc6ccccc6c15
form
powder
composition
Dye content, ≥75%
technique(s)
titration: suitable
color
green to very dark green
solubility
water: 0.01 g/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
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This Item | 21980 | 1340009 | B6756 |
|---|---|---|---|
| technique(s) titration: suitable | technique(s) titration: suitable | technique(s) - | technique(s) - |
| color green to very dark green | color green to very dark green | color - | color blue-green |
| form powder | form powder | form - | form powder |
| solubility water: 0.01 g/mL | solubility water: 0.01 g/10 mL | solubility - | solubility H2O: 1 mg/mL |
| application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing | application(s) pharmaceutical (small molecule) | application(s) diagnostic assay manufacturing |
| composition Dye content, ≥75% | composition - | composition - | composition Dye content, ≥85% |
Analysis Note
solubility: 0.01g in 10mL H2O : green to very dark green
Application
General description
Cardiogreen is a negatively charged polymethine dye that forms noncovalent fluorescent complexes with proteins. This "pseudofluorogenic" property has been utilized for protein determination by capillary electrophoresis with diode laser-induced fluorescence detection.[3]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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E M McCorquodale et al.
Electrophoresis, 22(12), 2403-2408 (2001-08-25)
Indocyanine green (ICG)--a negatively charged, polymethine dye--can interact noncovalently with proteins to form fluorescent complexes, with excitation and emission maxima near 780 and 820 nm, respectively. This behavior was realized utilizing either a 100 mM phosphate buffer or a 25
Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes.
Huang AS et al.
Translational vision science & technology, 5, 5-5 (2016)
Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.
Irwin D et al.
American Journal of Respiratory Cell and Molecular Biology, 42, 200-200 (2010)
Toshiki Endo et al.
Journal of neurosurgery. Spine, 18(5), 443-449 (2013-03-12)
The characteristics and efficacy of indocyanine green (ICG) videoangiography in cavernous malformation (CM) have not been fully elucidated. The purpose of this paper is to examine the potential utility of ICG videoangiography in the surgical treatment of intramedullary CMs. The
B E Schaafsma et al.
BJOG : an international journal of obstetrics and gynaecology, 120(6), 758-764 (2013-02-20)
This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received
Related Content
Product Information Sheet
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How long can I store a solution of Cardiogreen after it has been prepared?
1 answer-
Helpful?
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Does Cardiogreen dissolve equally well in saline and in water?
1 answer-
Each lot is tested for solubility in hot water at 1 mg/mL. We have found that Sigma Product No. I2633 (which has the same CAS number as Product No. 21980) dissolves in water at 1 mg/mL without heating. Further dilute in saline to prepare an isotonic solution.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Helpful?
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Has Cardiogreen been used for in vivo optical imaging studies?
1 answer-
We do not subject this product to in vivo testing. However, one study documents the use of the product in a study with mice:For optical imaging, mice were injected intravenously with a mixture of 0.05 ml of 260 μM ICG (Cardiogreen) and 0.05 ml of 360 μM DTR (70,000 MW, Invitrogen) in saline (equivalent to 0.4 mg per kg or 7.4 μM initial concentration in blood).
Helpful?
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
Helpful?
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Can Product No. I2633, Cardiogreen, be used as a biological stain?
1 answer-
Limited absorbance in the visible region practically precludes the use of Indocyanine Green as a biological stain. See: Sigma-Aldrich Handbook of Dyes, Stains, and Indicators, Green, F. ed., p. 407.
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