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Merck

SML0235

CDPPB

≥98% (HPLC)

Synonym(s):

3-Cyano-N-1,3-diphenyl-1H-pyrazol-5-yl)benzamide

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About This Item

Empirical Formula (Hill Notation):
C23H16N4O
CAS Number:
781652-57-1
Molecular Weight:
364.40
UNSPSC Code:
12352200
PubChem Substance ID:
329825248
NACRES:
NA.77

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Product Name

CDPPB, ≥98% (HPLC)

SMILES string

O.O=C(Nc1cc(nn1-c2ccccc2)-c3ccccc3)c4cccc(c4)C#N

InChI

1S/C23H16N4O.H2O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20;/h1-15H,(H,25,28);1H2

InChI key

GZHZEGYXLNXEBV-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥5 mg/mL at warmed to 60 °C

storage temp.

2-8°C

Quality Level

100

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Show Differences

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This Item
SML0202SML1693SML1061
CDPPB ≥98% (HPLC)

Sigma-Aldrich

SML0235

CDPPB

DPH ≥98% (HPLC)

Sigma-Aldrich

SML0202

DPH

Pz-1 ≥98% (HPLC)

Sigma-Aldrich

SML1693

Pz-1

PF-04856264 ≥98% (HPLC)

Sigma-Aldrich

SML1061

PF-04856264

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥5 mg/mL at warmed to 60 °C

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 1 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

color

white to beige

color

white to tan

color

white to beige

color

white to light brown

Application

CDPPB may be used in mGluR5-mediated cell signaling studies.

Biochem/physiol Actions

Activation of metabotropic glutamate 5 receptor by CDPPB enhances the function of NMDA receptor and markers of neuronal plasticity. This improves recognition memory and cognition deficits in schizophrenia.[1][2]
CDPPB is a glutamate metabotropic mGluR5 positive allosteric modulator.
CDPPB is an mGluR5 positive allosteric modulator

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000480029
0000472321
0000472321
0000070249
0000070250

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Jason M Uslaner et al.
Neuropharmacology, 57(5-6), 531-538 (2009-07-25)
In the search for strategies to treat schizophrenia, attention has focused on enhancing NMDA receptor function. In vitro experiments show that metabotropic glutamate 5 receptor (mGluR5) activation enhances NMDA receptor activity, and in vivo experiments indicate that mGluR5 positive allosteric
Hyejin Lee et al.
PLoS biology, 17(6), e2005326-e2005326 (2019-06-06)
Netrin-G ligand-3 (NGL-3) is a postsynaptic adhesion molecule known to directly interact with the excitatory postsynaptic scaffolding protein postsynaptic density-95 (PSD-95) and trans-synaptically with leukocyte common antigen-related (LAR) family receptor tyrosine phosphatases to regulate presynaptic differentiation. Although NGL-3 has been
Christina Gobin et al.
Psychopharmacology, 237(1), 115-125 (2019-08-26)
Cocaine use disorder (CUD) remains difficult to treat with no FDA-approved medications to reduce relapse. Antagonism of metabotropic glutamate receptor 5 (mGlu5) has been demonstrated to decrease cocaine-seeking but may also further compromise cognitive function in long-term cocaine users. Here we
J G Doria et al.
British journal of pharmacology, 169(4), 909-921 (2013-03-16)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein. We have previously demonstrated that the cell signalling of the metabotropic glutamate receptor 5 (mGluR5) is altered in a mouse model of
Patrick K McCamphill et al.
Science translational medicine, 12(544) (2020-05-22)
Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies in the Fmr1-/y mouse model of fragile X syndrome indicate that aberrant
View All Related Papers

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