I6125

Iodoacetamide

≥99% (NMR), crystalline

• Synonym(s): α-Iodoacetamide, 2-Iodoacetamide
• Linear Formula: ICH₂CONH₂
• CAS Number: 144-48-9
• Molecular Weight: 184.96
• Beilstein: 1739080
• EC Number: 205-630-1
• MDL number: MFCD00008028
• PubChem Substance ID: 24896083
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 300
• Assay: ≥99% (NMR)
• form: crystalline
• mp: 92-95 °C (lit.)
• solubility: H₂O: soluble 0.5 M, clear, colorless
• storage temp.: 2-8°C
• SMILES string: NC(=O)CI
• InChI: 1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
• InChI key: PGLTVOMIXTUURA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibiting ribonuclease.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H301 - H317 - H334 - H413
• Precautionary Statements: P261 - P264 - P273 - P280 - P301 + P310 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves