Dextromethorphan is a drug of the morphinan class. It is a cough suppressant with sedative, dissociative, and stimulant properties (at higher doses) and it is the active ingredient in many over-the-counter cold and cough medicines.
This application note illustrate how Silica Gel G plates are suitable for the analysis of Dextromethorphan following the European pharmacopeia identification TLC test experimental conditions (version 9.0).
Figure 1.Dextromethorphan Hydrobromide
Figure 2.TLC plate development
Figure 5.Chromatographic Data (Standard Solution)
Figure 6.Chromatographic Data (Sample Solution)