Dapsone

Name: Dapsone
Brand: SIAL
Price: 76.5 CAD

VETRANAL^®, analytical standard

Synonyme(s) :

Sulfone de 4-aminophényle, DDS

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A propos de cet article

Formule linéaire :

(H₂NC₆H₄)₂SO₂

Numéro CAS:

80-08-0

Poids moléculaire :

248.30

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329757089

EC Number:

201-248-4

Beilstein/REAXYS Number:

788055

MDL number:

MFCD00007887

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Nom du produit

Dapsone, VETRANAL^®, analytical standard

InChI key

MQJKPEGWNLWLTK-UHFFFAOYSA-N

InChI

1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2

SMILES string

Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2

grade

analytical standard

product line

VETRANAL^®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

175-177 °C (lit.)

application(s)

cleaning products
clinical
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

format

neat

Quality Level

200

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Catégories apparentées

Chromatographie analytique

Documents de référence

Normes relatives aux composants alimentaires et cosmétiques

Étalons de chromatographie

Étalons de substances réglementées et de drogues illicites

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Cet article	PHR1464	D0100000	1164008
Supelco 46158 Dapsone	Supelco PHR1464 Dapsone	D0100000 Dapsone	USP 1164008 Dapsone
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) -
application(s) cleaning products clinical cosmetics food and beverages forensics and toxicology personal care pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
Quality Level 200	Quality Level 300	Quality Level -	Quality Level -
grade analytical standard	grade certified reference material, pharmaceutical secondary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
shelf life limited shelf life, expiry date on the label	shelf life -	shelf life -	shelf life -

Application

Dapsone may be used as an analytical reference standard for the quantification of the analyte in animal samples[1] and pharmaceutical formulations[2] using different analytical techniques

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Dapsone is a synthetic antibiotic belonging to the class of sulfonamides, which show inhibitory action against most gram-positive and many gram-negative organisms.[1]

This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS08,GHS07,GHS09

signalword

Danger

hcodes

H302,H360F,H371,H373,H411

pcodes

P202 - P260 - P264 - P273 - P301 + P312 - P308 + P311

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 1B - STOT RE 2 - STOT SE 2

target_organs

Blood, Blood,spleen,Liver

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number

BCCJ3740

BCBX0187

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Determination of sulfonamides in animal tissues using cation exchange reversed phase sorbent for sample cleanup and HPLC-DAD for detection.

Hela W, et al.

Food Chemistry, 83(4), 601-608 (2003)

HLA-B*13:01 and the dapsone hypersensitivity syndrome.

F-R Zhang et al.

The New England journal of medicine, 369(17), 1620-1628 (2013-10-25)

Dapsone is used in the treatment of infections and inflammatory diseases. The dapsone hypersensitivity syndrome, which is associated with a reported mortality of 9.9%, develops in about 0.5 to 3.6% of persons treated with the drug. Currently, no tests are

A spectrophotometric method for the determination of metoclopramide HCl and dapsone

Revanasidadappa D.H and Manju B

Journal of Pharmaceutical and Biomedical Analysis, 25(3-4), 631-637 (2001)

Rapid synthesis of sulfone derivatives as potential anti-infectious agents.

C Curti et al.

European journal of medicinal chemistry, 42(6), 880-884 (2007-02-27)

An original one-pot microwave reaction was developed for the synthesis of sulfone derivatives as new potent antimicrobial agents. This eco-friendly methodology conducted in 30min led to desired products with good yields. The sulfones (4a and 4b) were obtained via the

Efficacy of dapsone in the treatment of pemphigus and pemphigoid: analysis of current data.

Hakan M Gürcan et al.

American journal of clinical dermatology, 10(6), 383-396 (2009-10-15)

Dapsone is a chemotherapeutic agent primarily used in treating leprosy, Pneumocystis jiroveci (previously carinii) pneumonia, and malaria. It is also used as an adjuvant in the treatment of pemphigus and pemphigoid. To assess the role of dapsone in the treatment

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