D2955000

Domperidone

Name: Domperidone
Brand: SIAL
Price: 176 CAD

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₂H₂₄ClN₅O₂

Numéro CAS:

57808-66-9

Poids moléculaire :

425.91

NACRES:

NA.24

PubChem Substance ID:

329798765

UNSPSC Code:

41116107

MDL number:

MFCD00069256

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Nom du produit

Domperidone, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

SMILES string

Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1

InChI key

FGXWKSZFVQUSTL-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

domperidone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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Catégories apparentées

Analytical Chemistry

Analytical Reference Materials for Pharma QC

Pharmacopeia & Metrological Institute Standards

Reference Materials

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1 of 4

Cet article	D122	D2957000	D3100000
D2955000 Domperidone	Sigma-Aldrich D122 Domperidone	D2957000 Domperidone maleate	D3100000 Droperidol
grade pharmaceutical primary standard	grade -	grade pharmaceutical primary standard	grade pharmaceutical primary standard
manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename EDQM	manufacturer/tradename EDQM
application(s) pharmaceutical (small molecule)	application(s) -	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format -	format neat	format neat
API family domperidone	API family -	API family domperidone	API family droperidol

Application

Domperidone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

related product

Réf. du produit

Description

Tarif

D2957000

Domperidone maleate, European Pharmacopoeia (EP) Reference Standard

BP669

Domperidone maleate, British Pharmacopoeia (BP) Reference Standard

pictograms

GHS08

signalword

Warning

hcodes

H361fd

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Domperidone: limited benefits with significant risk for sudden cardiac death.

Luc M Hondeghem

Journal of cardiovascular pharmacology, 61(3), 218-225 (2012-11-29)

Domperidone (antinausea/vomiting agent) was recently shown by several groups to increase sudden cardiac death (SCD). Drug-induced disturbances of cardiac repolarization may be a major mechanism. Experiments were executed in isolated female rabbit hearts perfused for 150 minutes with domperidone 30

Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old.

D S Pritchard et al.

British journal of clinical pharmacology, 59(6), 725-729 (2005-06-14)

To determine whether there is robust evidence of efficacy for domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) in children. Systematic review of randomized controlled trials (RCTs). A search was made of the Cochrane

Domperidone, a new dopamine antagonist.

M C Champion et al.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 135(5), 457-461 (1986-09-01)

Domperidone is a dopamine antagonist that has recently been released in Canada. Unlike metoclopramide hydrochloride, the other available dopamine antagonist, it does not readily enter the central nervous system. Domperidone acts as both an antiemetic and an upper gastrointestinal tract

Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial).

Elizabeth V Asztalos et al.

BMC pregnancy and childbirth, 12, 87-87 (2012-09-01)

The use of mother's own breast milk during initial hospitalization has a positive impact not only in reducing potential serious neonatal morbidities but also contribute to improvements in neurodevelopmental outcomes. Mothers of very preterm infants struggle to maintain a supply

Use of metoclopramide, domperidone, and cisapride in the management of diabetic gastroparesis.

C K Brown et al.

Clinical pharmacy, 9(5), 357-365 (1990-05-01)

The pathophysiology, diagnosis, and treatment of diabetic gastroparesis are reviewed, and the mechanisms of action, pharmacokinetics, clinical efficacy, adverse effects, and dosage of metoclopramide, domperidone, and cisapride are described. Diabetic gastroparesis is a state of delayed gastric emptying that reportedly

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