A3262

Adenosine 3′,5′-cyclic monophosphate tris salt

Name: Adenosine 3′,5′-cyclic monophosphate tris salt
Brand: SIGMA
Price: 463 CAD

≥97% (HPLC), synthetic, powder

Synonyme(s) :

cAMP, cyclic AMP

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₀H₁₂N₅O₆P · C₄H₁₁NO₃

Numéro CAS:

102029-77-6

Poids moléculaire :

450.34

UNSPSC Code:

41106305

eCl@ss:

32160414

PubChem Substance ID:

329770822

NACRES:

NA.51

MDL number:

MFCD00058346

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Nom du produit

Adenosine 3′,5′-cyclic monophosphate tris salt, ≥97% (HPLC), powder

SMILES string

NC(CO)(CO)CO.Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O

InChI

1S/C10H12N5O6P.C4H11NO3/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;5-4(1-6,2-7)3-8/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);6-8H,1-3,5H2/t4-,6-,7-,10-;/m1./s1

InChI key

CLDDYJFNXTUHIN-MCDZGGTQSA-N

biological source

synthetic

assay

≥97% (HPLC)

form

powder

color

white

solubility

H₂O: 100 mg/mL

storage temp.

−20°C

Quality Level

200

Catégories apparentées

Phosphates

Comparer avec des articles similaires

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1 of 4

Cet article	A9376	A0386	A9501
Sigma-Aldrich A3262 Adenosine 3′,5′-cyclic monophosphate tris salt	Sigma-Aldrich A9376 Adenosine 2′:3′-cyclic monophosphate sodium salt	Sigma-Aldrich A0386 Adenosine 3′-monophosphate sodium salt	Sigma-Aldrich A9501 Adenosine 3′,5′-cyclic monophosphate
biological source synthetic	biological source synthetic (organic)	biological source yeast	biological source -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
assay ≥97% (HPLC)	assay ≥93%	assay ≥98% (HPLC)	assay ≥98.5% (HPLC)
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
color white	color -	color -	color white

Application

Adenosine 3′,5′-cyclic monophosphate tris salt has been used as a medium supplement for human endometrial stromal cells (hESCs) culture[1] and induced neural stem cells (iNSCs).[2] It has been used in the spectroscopic characterization of pink flamindo, a red cAMP indicator.[3]

Biochem/physiol Actions

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

General description

Adenosine 3′,5′-cyclic monophosphate (cAMP) is synthesized from ATP in the presence of Adenylate cyclase enzyme. cAMP is majorly used as a marker in immunochemical detection assays.[4] Intracellular levels of cAMP control immune and inflammatory functions. Bacterial infection triggers intracellular cAMP production.[5] Elevated levels of cAMP modulates mitogen-activated protein kinase (MAPK) in cancer. An altered cAMP level is implicated in pathogenesis of cataract and cardiovascular disease. A decrease in cAMP levels triggers impaired insulin secretion in diabetes.[6]

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

0000425160

0000364881

SLCF8554

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Targeted ablation of Wnt4 and Wnt5a in Müllerian duct mesenchyme impedes endometrial gland development and causes partial Müllerian agenesis.

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Adenosine 3′,5′-cyclic monophosphate tris salt

≥97% (HPLC), synthetic, powder

Sélectionner une taille de conditionnement