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C4063
C Reactive Protein from human fluids
buffered aqueous solution
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human fluids
Essai
≥90% (SDS-GE)
Forme
buffered aqueous solution
Numéro d'accès UniProt
Application(s)
cell analysis
Température de stockage
2-8°C
Informations sur le gène
human ... CRP(1401)
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Cet article | C1617 | R9388 | 236600 |
|---|---|---|---|
| biological source human fluids | biological source - | biological source human urine | biological source - |
| assay ≥90% (SDS-GE) | assay - | assay ≥85% (SDS-GE) | assay - |
| form buffered aqueous solution | form liquid | form buffered aqueous solution | form liquid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
| Gene Information human ... CRP(1401) | Gene Information human ... CRP(1401) | Gene Information human ... RBP1(5947) | Gene Information - |
Description générale
C Reactive Protein (CRP) is a homopentameric protein, which belongs to the pentraxin family. It is produced in liver hepatocytes, smooth muscle cells, macrophages and adipocytes. CRP gene is located on human chromosome 1q23.2.[1]
Application
C Reactive Protein from human fluids has been used:
- to investigate the neutrophil extracellular traps (NETs)-dependent generation of monomeric CRP (mCRP) from pentameric CRP (pCRP)[2]
- to evaluate its effects on areas at risk (AAR) of myocardium with ischemia-reperfusion injury[3]
- to measure intracellular levels of reactive oxygen species (ROS)[4]
Actions biochimiques/physiologiques
C Reactive Protein (CRP) plays a critical role in apoptosis, phagocytosis, nitric oxide (NO) release and the secretion of cytokines, such as interleukin-6 and tumor necrosis factor-α. CRP acts as a marker for cardiovascular diseases, rheumatoid arthritis and cancer.[1]
C reactive protein (CRP) is an acute phase protein. Serum levels in patients with atherosclerosis is predictive of increased risk of myocardial infarction (MI) and stroke. The cytokine IL-6 is thought to be the key mediator in hepatocyte secretion of acute phase proteins including CRP. CRP mediates innate immunity by binding to microbial polysaccharides and to ligands exposed on damaged cells. The binding activates the classical complement pathway (C1, C4, C2, C3 but not C5-9). Opsonization of the substrates leads to their uptake by phagocytic cells and limits the inflammatory response.
C reactive protein (CRP) is an acute phase protein. Serum levels in patients with atherosclerosis is predictive of increased risk of myocardial infarction (MI) and stroke. The cytokine IL-6 is thought to be the key mediator in hepatocyte secretion of acute phase proteins including CRP. CRP mediates innate immunity by binding to microbial polysaccharides and to ligands exposed on damaged cells. The binding activates the classical complement pathway (C1, C4, C2, C3 but not C5-9). Opsonization of the substrates leads to their uptake by phagocytic cells and limits the inflammatory response.
Conditionnement
Package size based on protein content.
Forme physique
Solution in 0.02 M Tris, 0.28 M sodium chloride, 0.005 M calcium chloride, pH 7.8 - 8.2, containing 0.1% sodium azide.
Remarque sur l'analyse
Protein determined by Lowry.
Autres remarques
CRP is isolated from human fluids (Ascitic/Pleural).
Clause de non-responsabilité
Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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C-reactive protein (CRP) exerts biological activity on vascular endothelial cells. This activity may promote atherothrombosis, but the effects of this activity are still controversial. Lectin-like oxidized LDL receptor-1 (LOX-1), the oxidized LDL receptor on endothelial cells, is involved in endothelial
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To analyse the long-term relationship between disease activity and radiographic damage in the spine in patients with ankylosing spondylitis (AS). Patients from the Outcome in AS International Study (OASIS) were followed up for 12 years, with 2-yearly clinical and radiographic assessments.
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