The stability of this product in corn oil has not been investigated. However, various external sources indicate that Estradiol benzoate may be stored in aliquots at -80°C for 2 years and -20°C for 1 year when prepared at 2.5 mg/mL or greater in a mixture of 1 part DMSO and 9 parts corn oil.
E8515
β-Estradiol 3-benzoate
≥97%
Synonyme(s) :
1,3,5(10)-estratriène-3,17β-diol 3-benzoate, 3,17β-dihydroxy-1,3,5(10)-estratriène 3-benzoate
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E8515-200MG
80,10 $
E8515-1G
198,00 $
E8515-5G
683,00 $
80,10 $
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A propos de cet article
Formule empirique (notation de Hill) :
C25H28O3
Numéro CAS:
Poids moléculaire :
376.49
Beilstein:
3107526
Numéro CE :
Numéro MDL:
Code UNSPSC :
51111800
ID de substance PubChem :
Nomenclature NACRES :
NA.77
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Laissez-nous vous aiderNiveau de qualité
Essai
≥97%
Pf
191-198 °C (lit.)
Chaîne SMILES
[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OC(=O)c5ccccc5)ccc24
InChI
1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1
Clé InChI
UYIFTLBWAOGQBI-BZDYCCQFSA-N
Vous recherchez des produits similaires ? Visite Guide de comparaison des produits
1 of 4
Cet article | E1024 | E1132 | E2127 |
|---|---|---|---|
| assay ≥97% | assay - | assay - | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level - |
| mp 191-198 °C (lit.) | mp 176-180 °C (lit.) | mp 176-180 °C (lit.) | mp - |
Application
β-Estradiol 3-benzoate has been used:to mimic estradiol in rat during the oestrous cycle in rats.[1] It has also been used along with progesterone for the induction of sexual receptivity in female rat.[2]
Used in a study of general steroid metabolism and clearing, as groundwork for anabolic steroid screening in athletes.
Actions biochimiques/physiologiques
β-Estradiol 3-benzoate is a synthetic estrogen. It favors breast cancer progression.[3] It is an endocrine disrupting chemicals. It interacts with endocrine system and cause harmful effect on reproduction in animals and humans. It binds to estrogen receptors and favors tumor metastatis in breast, prostate and bone cells.[4]
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Carc. 2 - Repr. 1B
Code de la classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de danger pour l'eau (WGK)
WGK 3
Équipement de protection individuelle
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Electrochemical sensing of estradiol benzoate using hydroxyapatite with three-dimensional channel frameworks
Wen Y, et al.
Analytical Methods : Advancing Methods and Applications, 9(40), 5868-5872 (2017)
Sexual behavior increases cell proliferation in the rostral migratory stream and promotes the differentiation of the new cells into neurons in the accessory olfactory bulb of female rats
Corona R, et al.
Frontiers in Neuroscience, 10, 48-48 (2016)
M A Mohr et al.
Hormones and behavior, 111, 110-113 (2018-12-16)
In females, a hallmark of puberty is the luteinizing hormone (LH) surge that triggers ovulation. Puberty initiates estrogen positive feedback onto hypothalamic circuits, which underlie the stimulation of gonadotropin releasing hormone (GnRH) neurons. In reproductively mature female rodents, both estradiol
Enhancing Effects of beta-Estradiol 3-Benzoate but Not Methoxychlor on the Promotion/Progression Stage of Chemically-induced Mammary Carcinogenesis in Ovariectomized Rats
Ueda M, et al.
Japanese Journal of Cancer Research, 93(7), 752-759 (2002)
Acupuncture does not ameliorate metabolic disturbances in the P450 aromatase inhibitor-induced rat model of polycystic ovary syndrome
Maliqueo M, et al.
Experimental Physiology, 102(1), 113-127 (2017)
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If dissolved in corn oil, how is the stability? What is the recommended storage temperature and duration?
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How should stock solutions for the product β-Estradiol 3-benzoate (E8515) be stored?
1 answer-
Once the solution is prepared, it should be stored in separate packages to prevent product failure due to repeated freezing and thawing. The recommended storage period for the stock solution is as follows: when stored at -80°C, it should be used within 6 months; when stored at -20°C, it should be used within 1 month. To enhance solubility, the tube can be heated to 37°C and then agitated in an ultrasonic bath for a period of time.
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