N1537

NU7026

Name: NU7026
Brand: SIGMA
Price: 392 CAD

≥98% (HPLC), solid

Synonyme(s) :

2-(Morpholin-4-yl)-benzo[h]chromen-4-one

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5 MG

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₇H₁₅NO₃

Numéro CAS:

154447-35-5

Poids moléculaire :

281.31

NACRES:

NA.77

PubChem Substance ID:

329818582

UNSPSC Code:

12352200

MDL number:

MFCD06798345

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Nom du produit

NU7026, ≥98% (HPLC), solid

InChI

1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

SMILES string

O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

InChI key

KKTZALUTXUZPSN-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

tan

solubility

DMSO: soluble 3 mg/mL at 60 °C
H₂O: insoluble

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Catégories apparentées

Bioactive Small Molecule Inhibitors

Comparer avec des articles similaires

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1 of 4

Cet article	N7537	G0544	SML1109
Sigma-Aldrich N1537 NU7026	Sigma-Aldrich N7537 NSC 663284	Sigma-Aldrich G0544 GR 103691	Sigma-Aldrich SML1109 KU-55933
form solid	form solid	form solid	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: soluble 3 mg/mL at 60 °C, H₂O: insoluble	solubility DMSO: ≥10 mg/mL, H₂O: insoluble	solubility DMSO: soluble >5 mg/mL at 60 °C	solubility DMSO: 10 mg/mL, clear
color tan	color red	color white	color white to beige

Application

NU7026 has been used:

as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell[1]
in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)[2]
to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells[3]

Potent, ATP-competitive. IC₅₀ = 0.23 μM. Selectivity over other PI3K-related kinases (IC₅₀ = 13 μM for PI3K and >100 μM for ATM and ATR).

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

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Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma.

Rachel E Doherty et al.

Cancers, 11(9) (2019-09-05)

Uveal melanoma (UM) is the most common primary intraocular tumour in adults, with a mean survival of six months following metastasis. The survival rates have not improved in over 30 years. This study has shown that sister chromatid exchange (SCE)

Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair.

Takeshi Yasuda et al.

Genes to cells : devoted to molecular & cellular mechanisms, 26(5), 328-335 (2021-02-25)

SIRT2 and SIRT3 protein deacetylases maintain genome integrity and stability. However, their mechanisms for maintaining the genome remain unclear. To examine the roles of SIRT2 and SIRT3 in DSB repair, I-SceI-based GFP reporter assays for HR, single-strand annealing (SSA) and

The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo [def, p] chrysene on human hepatocellular cancer cell line HepG2

Spryszynska S, et al.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 791, 12-24 (2015)

DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR1.

Soichiro Shiga et al.

Biochemical and biophysical research communications, 521(3), 668-673 (2019-11-05)

Presence of unperfused regions containing cells under hypoxia and nutrient starvation; contributes to radioresistance in solid human tumors. We have previously reported that cultured cells; under nutrient starvation show resistance to ionizing radiation compare with cells under normal; condition, and

Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells

Rahal ON, et al.

Cancer Biology & Therapy, 17(11), 1139-1148 (2016)

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Contenu apparenté

Product Information Sheet - N1537

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