SML0330

S3I-201

Name: S3I-201
Brand: SIGMA
Price: 128 CAD

≥97% (HPLC)

Synonyme(s) :

2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid, NSC 74859

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A propos de cet article

Formule empirique (notation de Hill) :

C₁₆H₁₅NO₇S

Numéro CAS:

501919-59-1

Poids moléculaire :

365.36

NACRES:

NA.77

PubChem Substance ID:

329825335

UNSPSC Code:

12352200

MDL number:

MFCD09907564

Principaux documents

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Nom du produit

S3I-201, ≥97% (HPLC)

InChI

1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)

SMILES string

Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2

InChI key

HWNUSGNZBAISFM-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

Quality Level

100

Catégories apparentées

Bioactive Small Molecule Inhibitors

Comparer avec des articles similaires

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1 of 4

Cet article	SML1726	SML1492	SML1907
Sigma-Aldrich SML0330 S3I-201	Sigma-Aldrich SML1726 MSAB	Sigma-Aldrich SML1492 UMI-77	Sigma-Aldrich SML1907 ESI-05
form powder	form powder	form powder	form powder
assay ≥97% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. room temp
solubility DMSO: >10 mg/mL	solubility DMSO: 25 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 20 mg/mL, clear
color white to beige	color off-white to purple	color white to beige	color white to beige

Application

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells [1] and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)[2]
to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines[3]
to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells[4]

Biochem/physiol Actions

Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.[4]

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

S3I-201 is a cell-permeable Stat3 inhibitor.

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.

Kwang Bo Jung et al.

Nature communications, 9(1), 3039-3039 (2018-08-04)

Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal development and disease. However, hPSC-derived hIOs still require in vivo maturation

Runx1-Stat3-Tgfb3 signaling network regulating the anterior palatal development.

Safiye E Sarper et al.

Scientific reports, 8(1), 11208-11208 (2018-07-27)

Runx1 deficiency results in an anteriorly specific cleft palate at the boundary between the primary and secondary palates and in the first rugae area of the secondary palate in mice. However, the cellular and molecular pathogenesis underlying such regional specificity

Targeting STAT3 to Suppress Systemic Pro-Oncogenic Effects from Hepatic Radiofrequency Ablation.

Gaurav Kumar et al.

Radiology, 286(2), 524-536 (2017-09-08)

Purpose To (a) identify key expressed genes in the periablational rim after radiofrequency ablation (RFA) and their role in driving the stimulation of distant tumor growth and (b) use adjuvant drug therapies to block key identified mediator(s) to suppress off-target

Chlorogenic acid suppresses lipopolysaccharide‑induced nitric oxide and interleukin‑1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells.

Sang-Hun Kim et al.

Molecular medicine reports, 16(6), 9224-9232 (2017-10-11)

Chlorogenic acid (CA) is a phenolic compound purified from coffee, fruits and their associated beverages, which possess various biological properties, such as antioxidant and anticarcinogenic activities. The present study evaluated the effects of CA on lipopolysaccharide (LPS)‑induced inflammation in RAW264.7

Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells.

Kwang Bo Jung et al.

Journal of clinical medicine, 8(7) (2019-07-07)

Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the molecular and cellular biology of the intestine in vitro. We recently developed an in vitro maturation technique

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S3I-201

≥97% (HPLC)

Sélectionner une taille de conditionnement