T0682

Sodium taurohyodeoxycholate hydrate

Name: Sodium taurohyodeoxycholate hydrate
Brand: SIGMA
Price: 296 CAD

≥98%

Synonyme(s) :

Taurohyodeoxycholic acid sodium salt hydrate

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A propos de cet article

Formule linéaire :

C₂₆H₄₄NO₆SNa · xH₂O

Numéro CAS:

38411-85-7

Poids moléculaire :

521.69 (anhydrous basis)

Numéro MDL:

MFCD09263185

Code UNSPSC :

12161900

ID de substance PubChem :

24899908

Nomenclature NACRES :

NA.25

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Description

anionic

Essai

≥98%

Poids mol.

521.69 g/mol (anhydrous basis)

Application(s)

detection

Chaîne SMILES

O.[Na+].C[C@H](CCC(=O)NCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C26H45NO6S.Na.H2O/c1-16(4-7-24(30)27-12-13-34(31,32)33)19-5-6-20-18-15-23(29)22-14-17(28)8-10-26(22,3)21(18)9-11-25(19,20)2;;/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33);;1H2/q;+1;/p-1/t16-,17-,18+,19-,20+,21+,22+,23+,25-,26-;;/m1../s1

Clé InChI

MJKUJELEPWZEGU-IGEKTTBWSA-M

Catégories apparentées

Détergents - Anioniques, cationiques, zwitterioniques, anti-mousse

Produits biochimiques

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Cet article	T7515	G7132	T0557
Sigma-Aldrich T0682 Sodium taurohyodeoxycholate hydrate	Sigma-Aldrich T7515 Sodium taurolithocholate	Sigma-Aldrich G7132 Glycolate de sodium hydrate	Sigma-Aldrich T0557 Taurodéoxycholate de sodium hydrate
assay ≥98%	assay ≥97.0% (TLC)	assay ≥95% (TLC)	assay ≥97% (TLC)
application(s) detection	application(s) detection	application(s) -	application(s) -
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
description anionic	description anionic	description anionic	description anionic
mol wt 521.69 g/mol (anhydrous basis)	mol wt 505.69 g/mol	mol wt micellar avg mol wt 900(lit.)	mol wt micellar avg mol wt 3100

Description générale

Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent. [1]

Application

Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. [2] It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions. [3]

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Mechanism for the prevention of cholestasis involving cytochrome P4503A overexpression.

M Paolini et al.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 48(1), 49-59 (2000-03-01)

To clarify the preventive effect of taurohyodeoxycholic acid on liver cholestasis induced by toxic bile acids in rats, we evaluated whether modulation of cytochrome P4503A-linked oxidases is involved in the hepatic bile acid retention and secretion mechanism. We investigated whether

Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats.

Leonardo Baiocchi et al.

Journal of hepatology, 38(2), 136-147 (2003-01-28)

Taurohyodeoxycholate (THDCA) and tauroursodeoxycholate (TUDCA) induce more bile flow per molecule excreted compared to endogenous bile acids. The aim of this study is to determine if the hypercholeretic effect of tauroursodeoxycholate or taurohyodeoxycholate in normal and bile duct ligated (BDL)

Selective activation of liver X receptor alpha by 6alpha-hydroxy bile acids and analogs.

C Song et al.

Steroids, 65(8), 423-427 (2000-08-11)

We have found that certain natural 6alpha-hydroxylated bile acids are receptor-specific activators of nuclear liver X receptor alpha (LXRalpha) (NR1H3), a nuclear receptor regulating the expression of the cholesterol 7alpha-hydroxylase gene, coding for the rate-limiting enzyme in the major pathway

Immobilized artificial membrane chromatography: a rapid and accurate HPLC method for predicting bile salt-membrane interactions.

D E Cohen et al.

Journal of lipid research, 36(10), 2251-2260 (1995-10-01)

To predict bile salt-membrane interactions physiologically, we used an immobilized artificial membrane HPLC column that contains dimyristoyl-phosphatidylcholine molecules covalently linked to silica microspheres. Using a 90% aqueous (10% acetonitrile) mobile phase, 22 species of bile salts and 4 species of

Pharmacological studies on taurohyodeoxycholic acid.

A S Tripodi et al.

Arzneimittel-Forschung, 43(8), 877-880 (1993-08-01)

In this study we investigated the anticholelithogenic and choleretic activities and the general pharmacological action of taurohyodeoxycholic acid (THDCA, Io, Praxis, CAS 2958-04-5), a new biliary acid advocated for use as anticholelithogenic agent. THDCA had no significant activity on the

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Sodium taurohyodeoxycholate hydrate

≥98%

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