The use of T1875 for in vivo application was discussed and cited in the following article as a protocol reference: J Neuroendocrinol. 2015 Feb; 27(2): 100–110. The article is titled "Prenatal Testosterone Excess Decreases Neurokinin 3 Receptor Immunoreactivity within the Arcuate Nucleus KNDy cell population" with the PMID: 25496429.
T1875
Testosterone propionate
solid
Synonym(s):
17β-Hydroxy-4-androsten-3-one 17-propionate, 17β-Propionyloxy-4-androsten-3-one, 4-Androsten-17β-ol-3-one 17-propionate
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About This Item
Empirical Formula (Hill Notation):
C22H32O3
CAS Number:
Molecular Weight:
344.49
Beilstein:
3221760
EC Number:
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
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biological source
synthetic (organic)
Quality Level
sterility
non-sterile
Assay
≥98% (HPLC)
form
solid
drug control
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
color
white
solubility
acetone: soluble 1 in 4 of acetone
chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow
ethanol: soluble 1 in 6 of ethanol
ethyl oleate: soluble 1 in 20 of ethyl oleate
propylene glycol: soluble 1 in 30 of propylene glycol
soluble 1 in 20 of ethyl oleate
ethanol: 10 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.4 mg/mL
H2O: insoluble
oil: soluble
shipped in
ambient
storage temp.
room temp
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])OC(=O)CC
InChI
1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1
InChI key
PDMMFKSKQVNJMI-BLQWBTBKSA-N
Gene Information
human ... AR(367), CYP17A1(1586)
rat ... Ar(24208)
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This Item | PHR2026 | T0300000 | Y0001409 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| form solid | form solid | form - | form - |
| drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control - | drug control USDEA Schedule I | drug control - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| storage temp. room temp | storage temp. 2-30°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility acetone: soluble 1 in 4 of acetone, ethanol: soluble 1 in 6 of ethanol, propylene glycol: soluble 1 in 30 of propylene glycol, ethanol: 10 mg/mL, H2O: insoluble, chloroform: soluble 50 mg/ml, clear, colorless to faintly yellow, soluble 1 in 20 of ethyl oleate, oil: soluble, ethyl oleate: soluble 1 in 20 of ethyl oleate, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 4.4 mg/mL | solubility - | solubility - | solubility - |
Biochem/physiol Actions
Androgens direct the development of the male phenotype during embryogenesis and at puberty. Testosterone is an androgen that is secreted by the testis. This hormone is converted to dihydrotestosterone in the target tissues where it regulates several biological functions. Testosterone propionate has been synthetically derived from a plant. This product has extended and faster-acting functions when compared to other testosterone esters.
Physical form
Photosensitive solid
Preparation Note
This product is soluble in chloroform (50 mg/ml). It is also soluble in various oils. The oil solutions can be sterilized by maintaining at 150 deg C for 1 hour. It is practically insoluble in water, soluble 1 in 6 of ethanol, 1 in 4 of acetone, 1 in 20 of ethyl oleate, and 1 in 30 of propylene glycol. The product is incompatible with alkalis and oxidizing agents and it should be protected from light.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Repr. 1A
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Tsuyoshi Shimmura et al.
Scientific reports, 9(1), 3978-3978 (2019-03-10)
Animals that communicate using sound are found throughout the animal kingdom. Interestingly, in contrast to human vocal learning, most animals can produce species-specific patterns of vocalization without learning them from their parents. This phenomenon is called innate vocalization. The underlying
M E Rose et al.
Infection and immunity, 26(2), 630-637 (1979-11-01)
Comparisons were made between infections with Eimeria spp. in normal animals and in animals with functional deficiencies in either T-lymphocytes (athymic nude rats) or B-lymphocytes (bursectomized chickens). Approximately three times more oocysts of E. nieschulzi were passed during a primary
Maria Cernea et al.
Endocrinology, 156(9), 3277-3291 (2015-06-11)
Prenatal testosterone (T)-treated ewes display a constellation of reproductive defects that closely mirror those seen in PCOS women, including altered hormonal feedback control of GnRH. Kisspeptin/neurokinin B/dynorphin (KNDy) neurons of the arcuate nucleus (ARC) play a key role in steroid
Francois Mougeot et al.
Proceedings. Biological sciences, 276(1659), 1093-1100 (2009-01-09)
Extravagant ornaments evolved to advertise their bearers' quality, the honesty of the signal being ensured by the cost paid to produce or maintain it. The oxidation handicap hypothesis (OHH) proposes that a main cost of testosterone-dependent ornamentation is oxidative stress
Mohan Manikkam et al.
Biology of reproduction, 78(4), 648-660 (2007-12-21)
The goal of this study was to explore mechanisms that mediate hypersecretion of LH and progressive loss of cyclicity in female sheep exposed during fetal life to excess testosterone. Our working hypothesis was that prenatal testosterone excess, by its androgenic
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