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Merck

PIK3CA

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

Synonymes:
CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha
Espèce(s):
Human PIK3CA (5290), Mouse Pik3ca (18706), Rat Pik3ca (170911), sheep PIK3CA (101110015), chicken PIK3CA (424971), dog PIK3CA (488084), domestic guinea pig Pik3ca (100735084), naked mole-rat Pik3ca (101711934), domestic cat PIK3CA (101097413), cow PIK3CA (282306)
ID UniProtKB:
P42336, Q14CW1, Q99762
ID du gène:
  • Human(5290) Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008]
  • Mouse(18706) phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • Rat(170911) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • sheep(101110015) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • chicken(424971) phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • dog(488084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic guinea pig(100735084) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • naked mole-rat(101711934) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • domestic cat(101097413) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
  • cow(282306) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

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Antibodies

Numéro du produit
Description
Espèces réactives
Application
ZRB1712
Anti-PI-3 kinase p110α Antibody, clone 1J4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, monkey
Application
affinity binding assay
flow cytometry
immunohistochemistry
western blot
SAB5700234
Anti-PIK3CA antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
SAB2701957
Anti-PIK3CA antibody produced in rabbit, ,
Espèces réactives
human, mouse
Application
immunofluorescence
immunohistochemistry
western blot
AMAB91514
Monoclonal Anti-PIK3CA antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8347, purified immunoglobulin, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
WH0005290M1
Monoclonal Anti-PIK3CA antibody produced in mouse, clone 3G3, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
proximity ligation assay

Cell Lines

Numéro du produit
Description
Espèce(s)
CLLS1003
DLD1 Cells PIK3CA +/-, ,
Espèce(s)
human
CLLS1199
MCF10A CELLS PTEN (-/-) PIK3CA H1047R (+/-), ,
Espèce(s)
human

Kits

Numéro du produit
Description
Espèce(s)
33-016
PI 3-Kinase HTRF® Assay; 384 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 1 plate.,
Espèce(s)
human
33-047
PI 3-Kinase 3-step HTRF® Assay, The PI 3-Kinase 3-Step HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format.,
Espèce(s)
human
33-017
Test HTRF® de l′activité PI 3-kinase ; 1 920 puits, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 5 plates.,
Espèce(s)
human
33-037
PI 3-Kinase HTRF® Assay; 50,000 wells, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 50,000 wells.,
Espèce(s)
human
33-036
Test HTRF® de l′activité PI 3-kinase ; 10 000 puits, The PI 3-Kinase HTRF Assay is a high-performance assay kit that provides a universal method for testing all Class I PI3-Kinases in a homogeneous format. This pack size has a screening capacity of 10,000 wells.,
Espèce(s)
human

Proteins

Numéro du produit
Description
Espèce(s)
14-783-M
PI3 Kinase (p110α(E545K)/p85α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length human p110α containing the mutation E545K & untagged, recombinant, full-length human p85α. For use in Kinase Assays.,
Espèce(s)
human
SRP0233
PI3 kinase (p110a/p85a) Active human, recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE),
Espèce(s)
human
14-602-M
PI3 Kinase (p110α/p85α) Protein, active, 20 µg, Active complex of N-terminal His6-tagged recombinant full-length human p110α & untagged, recombinant, full length, human p85α. For use in Kinase Assays.,
Espèce(s)
human
14-790-M
PI3 Kinase (p110α/p65α), 10 µg, Complex of N-terminal 6His-tagged, recombinant, full-length Human p110α & untagged, recombinant, full length Human p65α. For use in Kinase Assays.,
Espèce(s)
human
SRP5280
PI3K (p110-α/p85-α), active, His tagged from mouse and human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
mouse

esiRNA

Numéro du produit
Description
Espèce(s)
EHU231281
MISSION® esiRNA, targeting human PIK3CA (2),
Espèce(s)
human
EHU039391
MISSION® esiRNA, targeting human PIK3CA,
Espèce(s)
human
EMU053821
MISSION® esiRNA, targeting mouse Pik3ca,
Espèce(s)
mouse