E1132

17β-Estradiol

ER agonist

• Synonyma: 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
• Empirický vzorec (Hillův zápis): C₁₈H₂₄O₂
• Číslo CAS: 50-28-2
• Molekulová hmotnost: 272.38
• NACRES: NA.77
• PubChem Substance ID: 24894389
• UNSPSC Code: 12352104
• EC Number: 200-023-8
• MDL number: MFCD00003693
• Beilstein/REAXYS Number: 1914275

Vlastnosti

• Název produktu: β-Estradiol, analytical standard
• grade: analytical standard
• Quality Segment: 200
• packaging: vial of 250 mg
• technique(s): HPLC: suitable, chromatography: suitable, gas chromatography (GC): suitable
• mp: 176-180 °C (lit.)
• application(s): pharmaceutical
• SMILES string: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• InChI key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Gene Information: human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866) ; mouse ... Esr1(13982), Esr2(13983), Esrra(26379) ; rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

Popis

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary.

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Packaging

Supplied in amber screw-cap vials

Bezpečnostní informace

• Piktogramy: GHS08,GHS09
• Výstražné slovo: Danger
• Kódy nebezpečí: H351,H360Fd,H362,H410,EUH380,EUH430
• Bezpečnostní pokyny: P201 - P202 - P260 - P263 - P273 - P280 - P308 + P313 - P391 - P405 - P501
• Hazard Classifications: Aquatic Chronic 1 - Carc. 2 - ED ENV 1 - ED HH 1 - Lact. - Repr. 1A
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable
• PPE (osobní ochranné prostředky): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges