G8415

L-Glutamic acid

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

• Synonyma: (S)-2-Aminopentanedioic acid, Glu
• Lineární vzorec: HO₂CCH₂CH₂CH(NH₂)CO₂H
• Číslo CAS: 56-86-0
• Molekulová hmotnost: 147.13
• PubChem Substance ID: 24895340
• eCl@ss: 32160406
• UNSPSC Code: 12352209
• NACRES: NA.26
• EC Number: 200-293-7
• MDL number: MFCD00002634
• Beilstein/REAXYS Number: 1723801

Vlastnosti

• Název produktu: L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
• biological source: non-animal source
• Quality Segment: 300
• agency: meets EP testing specifications
• assay: 98.5-100.5%
• form: powder
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• color: white
• mp: 205 °C (dec.) (lit.)
• solubility: 1 M HCl: 100 mg/mL
• density: 1.54 g/cm³ at 20 °C
• anion traces: chloride (Cl^-): ≤200 ppm, sulfate (SO₄^2-): ≤200 ppm
• cation traces: As: ≤1 ppm, passes test, Fe: ≤10 ppm, passes test, NH₄⁺: ≤200 ppm, passes test
• application(s): advanced drug delivery; pharmaceutical (small molecule)
• SMILES string: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• InChI key: WHUUTDBJXJRKMK-VKHMYHEASA-N
• Gene Information: human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506) ; rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482) ;

Popis

Application

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid. Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity. It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids. In cells, glutamine is converted to glutamate by the enzyme glutaminase. Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Co se děje?: WGK 1
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable
• PPE (osobní ochranné prostředky): Eyeshields, Gloves, type N95 (US)