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P0018

Pomalidomide

Name: Pomalidomide
Brand: SIGMA

≥98% (HPLC), powder, HbF inducer

Synonyma:

1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3

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O této položce

Empirický vzorec (Hillův zápis):

C₁₃H₁₁N₃O₄

Číslo CAS:

19171-19-8

Molekulová hmotnost:

273.24

UNSPSC Code:

12352200

PubChem Substance ID:

329819974

NACRES:

NA.77

MDL number:

MFCD12756407

Assay:

≥98% (HPLC)

Form:

powder

Technický servis

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Vlastnosti

Název produktu

Pomalidomide, ≥98% (HPLC)

ligand

pomalidomide

Quality Segment

100

assay

≥98% (HPLC)

form

powder

reaction suitability

reagent type: ligand

technique(s)

targeted protein degradation: suitable

color

yellow

solubility

DMSO: ≥14 mg/mL

storage temp.

2-8°C

SMILES string

Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

InChI

1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChI key

UVSMNLNDYGZFPF-UHFFFAOYSA-N

Gene Information

human ... CRBN(51185), CUL4A(8451), DDB1(1642), RBX1(9978)

Popis

Application

Pomalidomide has been used:

to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
for apoptosis studies and intracellular calcium analysis
as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells

Biochem/physiol Actions

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramy

GHS08

Výstražné slovo

Danger

Kódy nebezpečí

H360D

Bezpečnostní pokyny

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Skladovací třída

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Bod vzplanutí (°F)

Not applicable

Bod vzplanutí (°C)