P4157

Phe-Arg β-naphthylamide dihydrochloride

cathepsin substrate, fluorogenic, ≥98% (TLC), powder

• Synonyma: PAβN
• Empirický vzorec (Hillův zápis): C₂₅H₃₀N₆O₂ · 2HCl
• Číslo CAS: 100929-99-5
• Molekulová hmotnost: 519.47
• UNSPSC Code: 12352204
• PubChem Substance ID: 24898508
• NACRES: NA.32
• MDL number: MFCD00058046

Vlastnosti

• Název produktu: Phe-Arg β-naphthylamide dihydrochloride, cathepsin substrate
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2
• InChI: 1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H
• InChI key: ZMTAZQYLEGNUTJ-UHFFFAOYSA-N

Popis

General description

Phe-Arg β-naphthylamide, a peptidomimetic compound, is an efflux pump inhibitor (EPI). It acts on the major multidrug resistance efflux transporters of Gram-negative bacteria. Phe-Arg -naphthylamide lowers fluoroquinolone resistance in Pseudomonas aeruginosa.

Substrate for dipeptidyl aminopeptidase I (cathepsin C).

Application

Phe-Arg -naphthylamide dihydrochloride has been used to evaluate the contribution of efflux pumps to antimicrobial resistance. It has also been used for minimal inhibitory concentration testing in the presence of an efflux pump inhibitor.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Bezpečnostní informace

• Skladovací třída: 11 - Combustible Solids
• Co se děje?: WGK 3
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable
• PPE (osobní ochranné prostředky): Eyeshields, Gloves, type N95 (US)