1176007

Dexamethasone

United States Pharmacopeia (USP) Reference Standard

• Synonyma: (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F
• Empirický vzorec (Hillův zápis): C₂₂H₂₉FO₅
• Číslo CAS: 50-02-2
• Molekulová hmotnost: 392.46
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329749548
• MDL number: MFCD00064136
• Beilstein/REAXYS Number: 2066651

Vlastnosti

• biological source: synthetic
• grade: pharmaceutical primary standard
• agency: USP
• vapor pressure: <0.0000001 kPa ( 25 °C)
• API family: dexamethasone
• packaging: pkg of 125 mg
• manufacturer/tradename: USP
• color: white
• mp: 262-264 °C (lit.)
• solubility: acetone: sparingly soluble, chloroform: slightly soluble, ethanol: sparingly soluble, ether: very slightly soluble, methanol: sparingly soluble, water: practically insoluble
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
• InChI: 1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
• InChI key: UREBDLICKHMUKA-CXSFZGCWSA-N
• Gene Information: human ... NR3C1(2908)

Popis

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Dexamethasone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Ciprofloxacin and Dexamethasone Otic Suspension
• Dexamethasone
• Dexamethasone Compounded Oral Suspension
• Dexamethasone Elixir
• Dexamethasone Injection
• Dexamethasone Ophthalmic Suspension
• Dexamethasone Oral Solution

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Bezpečnostní informace

• pictograms: GHS08
• signalword: Danger
• hcodes: H360FD
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable