1414003

Methotrexate

United States Pharmacopeia (USP) Reference Standard

• Synonyma: (+)-Amethopterin, 4-Amino-10-methylfolic acid, 4-Amino-N¹⁰-methylpteroyl-L-glutamic acid, Antifolan, MTX, Methylaminopterin
• Empirický vzorec (Hillův zápis): C₂₀H₂₂N₈O₅
• Číslo CAS: 59-05-2
• Molekulová hmotnost: 454.44
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750410
• MDL number: MFCD00064370
• Beilstein/REAXYS Number: 70669

Vlastnosti

• grade: pharmaceutical primary standard
• agency: USP
• API family: methotrexate
• manufacturer/tradename: USP
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
• InChI key: FBOZXECLQNJBKD-ZDUSSCGKSA-N
• Gene Information: human ... DHFR(1719)

Popis

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methotrexate USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Methotrexate Injection
• Methotrexate Tablets
• Methotrexate for Injection

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Bezpečnostní informace

• Piktogramy: GHS06,GHS08
• Výstražné slovo: Danger
• Kódy nebezpečí: H301,H341,H360D,H372
• Bezpečnostní pokyny: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 2 - Repr. 1B - STOT RE 1
• Cílové orgány: Liver,Bone marrow
• Skladovací třída: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Co se děje?: WGK 3
• Bod vzplanutí (°F): Not applicable
• Bod vzplanutí (°C): Not applicable