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Merck

324800

Epoxomicin

≥95% (HPLC), solid, proteasome inhibitor, Calbiochem®

Synonym(s):

Epoxomicin, Synthetic, Proteasome Inhibitor XIV

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100 μG

CZK 8,880.00

CZK 8,880.00

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About This Item

Empirical Formula (Hill Notation):
C28H50N4O7
Molecular Weight:
554.72
UNSPSC Code:
12352202
NACRES:
NA.77

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Product Name

Epoxomicin, Synthetic, Epoxomicin, Synthetic, CAS 134381-21-8, is a potent, specific, and irreversible inhibitor of chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide hydrolyzing activities of the proteasome.

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 1 mg/mL
methanol: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

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This Item
324801114802426100
Epoxomicin, Synthetic Epoxomicin, Synthetic, CAS 134381-21-8, is a potent, specific, and irreversible inhibitor of chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide hydrolyzing activities of the proteasome.

Sigma-Aldrich

324800

Epoxomicin, Synthetic

Epoxomicin InSolution, ≥95%

Sigma-Aldrich

324801

Epoxomicin

AdaAhx3L3VS A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.

Sigma-Aldrich

114802

AdaAhx3L3VS

Lactacystin, Synthetic Lactacystin, Synthetic, CAS 1258004-00-0, is an irreversible inhibitor of 20S proteasome inhibitor (IC50 = 500 nM). A covalent inhibitor of the chymotrypsin & trypsin-like activities of proteasome.

Sigma-Aldrich

426100

Lactacystin, Synthetic

form

solid

form

liquid

form

powder

form

solid

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

≥99% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 1 mg/mL, methanol: 1 mg/mL

solubility

-

solubility

DMSO: 5 mg/mL

solubility

DMSO: 50 mg/mL, water: soluble

Biochem/physiol Actions

Cell permeable: no
Primary Target
CT-L,T-L,PGPH activity of proteasome
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

An antitumor agent of microbial origin that acts as a potent, highly specific, and irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidylglutamyl peptide hydrolyzing (PGPH) activities of the proteasome. Modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z. Epoxomicin also displays potent anti-inflammatory activity in vivo.
An antitumor and anti-inflammatory agent that acts as a potent, highly specific, and irreversible inhibitor of chymotrypsin-like (CT-L), trypsin-like (T-L), and peptidyl-glutamyl peptide hydrolyzing (PGPH) activities of the proteasome. Modifies the proteasomal catalytic subunits LMP-7, MECL1, and Z. Does not affect the activities of non-proteasomal proteases such as trypsin, cathepsin B, or chymotrypsin. A 1 mM (50 µg/90 µl) solution of Epoxomicin, Synthetic (Cat. No. 324801) in DMSO is also available.

Other Notes

Meng, L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 10403.
Sin, N., et al. 1999. Bioorg. Med. Chem. Lett. 9, 2283.
Hanada, M., et al. 1992. J. Antibiot. 45, 1746.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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