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Merck

03762

2,6-Di-tert-butyl-4-methylphenol

tested according to Ph. Eur.

Synonym(s):

Butylhydroxytoluenum, 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

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500 G

CZK 3,790.00

CZK 3,790.00


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About This Item

Linear Formula:
[(CH3)3C]2C6H2(CH3)OH
CAS Number:
Molecular Weight:
220.35
UNSPSC Code:
12352300
NACRES:
NA.21
PubChem Substance ID:
EC Number:
204-881-4
Beilstein/REAXYS Number:
1911640
MDL number:

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Product Name

2,6-Di-tert-butyl-4-methylphenol, tested according to Ph. Eur.

InChI key

NLZUEZXRPGMBCV-UHFFFAOYSA-N

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

SMILES string

Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

agency

tested according to Ph. Eur.

vapor density

7.6 (vs air)

vapor pressure

<0.01 mmHg ( 20 °C)

autoignition temp.

878 °F

bp

265 °C (lit.)

mp

69-73 °C (lit.)

application(s)

pharmaceutical (small molecule)

Quality Level

Gene Information

human ... CAPN1(823)
rat ... Capn1(29153), Nos1(24598)

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1 of 4

This Item
34750B137847168
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

mp

69-73 °C (lit.)

mp

68-72 °C, 69-73 °C (lit.)

mp

69-73 °C (lit.)

mp

-

bp

265 °C (lit.)

bp

265 °C (lit.)

bp

265 °C (lit.)

bp

-

agency

USP/NF

agency

-

agency

-

agency

-

vapor density

7.6 (vs air)

vapor density

7.6 (vs air)

vapor density

7.6 (vs air)

vapor density

-

vapor pressure

<0.01 mmHg ( 20 °C)

vapor pressure

<0.01 mmHg ( 20 °C)

vapor pressure

<0.01 mmHg ( 20 °C)

vapor pressure

-

Application


  • Quantitative analysis of residual butylated hydroxytoluene and butylated hydroxyanisole in Salmo salar, milk, and butter by liquid chromatography-tandem mass spectrometry.: This study provides a quantitative analysis of residual 2,6-Di-tert-butyl-4-methylphenol (BHT) and butylated hydroxyanisole (BHA) in various food products. The research highlights the presence and concentration of these antioxidants in fish, milk, and butter, demonstrating their widespread use in food preservation (Galal et al., 2024).

  • The key factors of solid nanodispersion for promoting the bioactivity of abamectin.: This research investigates the use of BHT in solid nanodispersions to enhance the bioactivity of abamectin, a widely used insecticide. The study identifies key factors that improve the stability and effectiveness of the formulation, suggesting applications in agricultural biotechnology (Ding et al., 2024).

pictograms

Environment

signalword

Warning

hcodes

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

260.6 °F - open cup

flash_point_c

127 °C - open cup

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Li Li et al.
Circulation, 105(7), 861-867 (2002-02-21)
Current epidemiological data suggest that dental infections affecting tooth-supporting tissues (periodontitis) can disseminate into the systemic circulation and thereby contribute to atherosclerosis progression. To test this hypothesis, we investigated the effect of repeated systemic inoculations with Porphyromonas gingivalis (Pg), a
I Björkhem et al.
Arteriosclerosis and thrombosis : a journal of vascular biology, 11(1), 15-22 (1991-01-01)
Rabbits fed a 1% cholesterol diet with or without the antioxidant butylated hydroxytoluene (BHT) developed typical atherosclerotic lesions. The addition of BHT gave higher levels of total cholesterol (+40%), triglycerides (+250%), low density lipoprotein (LDL), and very low density lipoprotein
A M Vijesh et al.
European journal of medicinal chemistry, 46(11), 5591-5597 (2011-10-05)
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized
Butylated hydroxytoluene (BHT): a review.
H Babich
Environmental research, 29(1), 1-29 (1982-10-01)
Gen-ichiro Arimura et al.
Plant physiology, 146(3), 965-973 (2008-01-01)
Continuous mechanical damage initiates the rhythmic emission of volatiles in lima bean (Phaseolus lunatus) leaves; the emission resembles that induced by herbivore damage. The effect of diurnal versus nocturnal damage on the initiation of plant defense responses was investigated using

Questions

  1. Is it possible that p-cresol could be coming from this compound? Not sure if the tert butyl and methyl groups could hydrolyse in alkaline or acidic conditons. Trying to figure out how p-cresol gets into our wastewater and would appreciate any advice!

    1 answer
    1. The purity of the product is not specified and any possible impurities are not tested for, aside from heavy metals and residual solvents. P-cresol may be present as an impurity or a reaction product, depending on the use of the material. Ideally, the product nor its impurities should be entering a wastewater stream - any waste generated from the use of this material should be collected and disposed of as chemical waste. As per section 6 of the SDS, this product should not be entering drains.

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