8-Quinolinol

Name: 8-Quinolinol
Brand: SIAL
Price: 5120 CZK

puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99% (perchloric acid titration)

Synonym(s):

8-Hydroxyquinoline, 8-Oxychinolin, Oxine

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100 G

CZK 5,120.00

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About This Item

Empirical Formula (Hill Notation):

C₉H₇NO

CAS Number:

148-24-3

Molecular Weight:

145.16

UNSPSC Code:

12352100

NACRES:

NA.21

PubChem Substance ID:

57648688

EC Number:

205-711-1

Beilstein/REAXYS Number:

114512

MDL number:

MFCD00006807

Key Documents

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Product Name

8-Quinolinol, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99% (perchloric acid titration)

InChI key

MCJGNVYPOGVAJF-UHFFFAOYSA-N

InChI

1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H

SMILES string

Oc1cccc2cccnc12

grade

ACS reagent
puriss. p.a.

agency

reag. Ph. Eur.

assay

≥99% (perchloric acid titration)

form

solid

technique(s)

titration: suitable

impurities

≤0.05% insoluble in ethanol

ign. residue

≤0.05% (as SO₄)

mp

72.5-74.0 °C
72.5-75 °C

anion traces

chloride (Cl^-): ≤10 mg/kg
sulfate (SO₄^2-): ≤100 mg/kg

suitability

passes test for suitability for Mg decision

antibiotic activity spectrum

fungi

mode of action

DNA synthesis | interferes
enzyme | inhibits

Quality Level

200

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Show Differences

1 of 4

This Item	36524	H6878	8.20261
Sigma-Aldrich 32502 8-Quinolinol	Supelco 36524 8-Quinolinol	Sigma-Aldrich H6878 8-Hydroxyquinoline	Sigma-Aldrich 8.20261 8-Hydroxyquinoline
technique(s) titration: suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) -
grade ACS reagent	grade analytical standard	grade -	grade -
agency reag. Ph. Eur.	agency -	agency -	agency -
assay ≥99% (perchloric acid titration)	assay 98-100% (GC)	assay ≥98.5%	assay ≥99.0% (GC)
form solid	form -	form powder	form solid
impurities ≤0.05% insoluble in ethanol	impurities -	impurities -	impurities -

General description

8-Quinolinol (QOH) forms complexes with heavy metals [Pt(II), Pb(II), Bi(III), Ir(III)]. These complexes show long-lived phosphorescence and excited state absorption in solutions.[1] It has been reported to form metal chelate complexes.[2] Immobilized 8-quinolinol has been widely used in the preconcentration step during the extraction of metals.[3]

Chemical structure: quinolone

pictograms

GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H301,H317,H318,H360D,H410

pcodes

P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Synthesis, crystal structure and spectral properties of VO (acetylacetone benzoylhydrazone)(8-quinolinol).

Liu SX and Gao S.

Polyhedron, 17(1), 81-84 (1998)

The reactions of 8-quinolinol.

Phillips JP.

Chemical Reviews, 56(2), 271-297 (1956)

Phosphorescent 8-quinolinol metal chelates. Excited-state properties and redox behavior.

Ballardini R, et al.

Inorganic Chemistry, 25(22), 3858-3865 (1986)

Synthesis of silica-immobilized 8-quinolinol with (aminophenyl) trimethoxysilane.

Marshall MA and Mottola HA.

Analytical Chemistry, 55(13), 2089-2093 (1983)

Copper-dependent cytotoxicity of 8-hydroxyquinoline derivatives correlates with their hydrophobicity and does not require caspase activation.

Saverio Tardito et al.

Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)

This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and

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