PHR1125

L-Glutamine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): (S)-2,5-Diamino-5-oxopentanoic acid, L-Glutamic acid 5-amide, Levoglutamide
• Linear Formula: H₂NCOCH₂CH₂CH(NH₂)CO₂H
• CAS Number: 56-85-9
• Molecular Weight: 146.14
• NACRES: NA.24
• PubChem Substance ID: 329823146
• UNSPSC Code: 41116107
• EC Number: 200-292-1
• Beilstein/REAXYS Number: 1723797

Properties

• Product Name: L-Glutamine, Pharmaceutical Secondary Standard; Certified Reference Material
• InChI key: ZDXPYRJPNDTMRX-VKHMYHEASA-N
• InChI: 1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
• SMILES string: N[C@@H](CCC(N)=O)C(O)=O
• grade: certified reference material; pharmaceutical secondary standard
• agency: traceable to USP 1294808
• API family: glutamine
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 185 °C (dec.) (lit.)
• application(s): cleaning products; cosmetics; flavors and fragrances; food and beverages; personal care; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• Quality Level: 300

Description

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

L-Glutamine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using amperometric L-glutamate oxidase based enzyme sensors.[1]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels.[2]

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAA7149 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable