03907

Tioconazole

97%

• Synonym(s): 1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole
• Empirical Formula (Hill Notation): C₁₆H₁₃Cl₃N₂OS
• CAS Number: 65899-73-2
• Molecular Weight: 387.71
• PubChem Substance ID: 329747834
• UNSPSC Code: 51302325
• NACRES: NA.85
• EC Number: 265-973-8
• MDL number: MFCD00057276

Properties

• Product Name: Tioconazole, 97%
• SMILES string: Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1; Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
• InChI: 1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
• InChI key: QXHHHPZILQDDPS-UHFFFAOYSA-N
• assay: ≥96.5% (HPLC); 96.5-103.5% (NT); 97%
• form: powder
• color: white to off-white
• antibiotic activity spectrum: fungi; yeast
• mode of action: cell membrane | interferes
• Quality Level: 100

Description

Application

Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans[1] as well as significant drug-drug interactions in vivo[2].

Biochem/physiol Actions

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.

General description

Chemical structure: pyrimidine

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Packaging

10G

Safety Information

• pictograms: GHS08,GHS07,GHS09
• signalword: Warning
• hcodes: H302,H317,H361d,H410
• pcodes: P202 - P273 - P280 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves