This product is soluble in 1 M NH?OH (50 mg/ml), with heat as needed, yielding a clear, colorless solution. This product is also soluble in water (7 mg/ml). Other sources recommend dissolving Adenosine in DMSO at maximum concentration of 20 mg/mL.
A9251
Adenosine
≥99% (HPLC), powder, neurotransmitter
Adenosine
Synonym(s):
9-β-D-Ribofuranosyladenine, Adenine riboside, Adenine-9-β-D-ribofuranoside
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1 G
CZK 645.00
5 G
CZK 1,230.00
25 G
CZK 3,950.00
100 G
CZK 7,370.00
About This Item
Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
Molecular Weight:
267.24
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
32160413
UNSPSC Code:
12352200
EC Number:
200-389-9
MDL number:
Beilstein/REAXYS Number:
93029
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Product Name
Adenosine, ≥99%
InChI key
OIRDTQYFTABQOQ-KQYNXXCUSA-N
InChI
1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
assay
≥99%
form
powder
mp
234-236 °C (lit.)
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066)
rat ... Adcy2(81636), Adora1(29290), Adora2a(25369), Adora3(25370)
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Related Categories
1 of 4
This Item | A4036 | PHR1138 | 1012123 |
|---|---|---|---|
| assay ≥99% | assay ≥99% (HPLC) | assay - | assay - |
| form powder | form powder | form - | form - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
| mp 234-236 °C (lit.) | mp 234-236 °C (lit.) | mp 234-236 °C (lit.) | mp 234-236 °C (lit.) |
| Gene Information human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066) | Gene Information human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066) | Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) | Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) |
Application
Adenosine has been used:
- as a supplement in embryonic type culture medium for in vitro osteogenic differentiation[1]
- for evaluation of its effect on cell survival by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT assay) and cell proliferation by 3H-thymidine incorporation assay in multi drug resistant glioblastoma stem-like cells (GSCs), and as a standard in high performance liquid chromatography (HPLC).[2]
- as a constituent in collagenase solution for the collagenase digestion of mice fat tissue.[3]
Biochem/physiol Actions
Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).
Endogenous neurotransmitter. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
In the extracellular space, ecto-5′-nucleotidase (CD73) dephosphorylates adenosine triphosphate (ATP) to produce adenosine.[1][2] Adenosine has four receptors namely A1R, A2AR A2BR and A3R. Adenosine plays a key role in the osteogenic differentiation. A1R induces osteoclast differentiation and A2AR induces osteoblast differentiation.[1]
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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TGF beta-induced osteogenic potential of human amniotic fluid stem cells via CD73-generated adenosine production
Hau KL, et al.
Scientific Reports, 7(1), 6601-6601 (2017)
Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells
Sugii S, et al.
Nature Protocols, 6(3), 346-346 (2011)
Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells
Torres A, et al.
Oncotarget, 7(41), 67373-67373 (2016)
Jeffrey Buter et al.
Nature chemical biology, 15(9), 889-899 (2019-08-21)
Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. In the present study 1-TbAd has been shown to be a naturally evolved phagolysosome disruptor. 1-TbAd
Dominik Eichin et al.
PloS one, 10(8), e0134721-e0134721 (2015-08-11)
The ectoenzyme CD73 catalyzes the hydrolysis of AMP, and is one of the most important producers of extracellular adenosine. On regulatory T cells, CD73 is necessary for immunosuppressive functions, and on Th17 cells CD73-generated adenosine exerts anti-inflammatory effects. However, the
Articles
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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Hello, can you dissolve adenosine in DMSO? and to what concentration? Thank you.
1 answer-
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