This product has not been tested in-house for this application, so a recommendation cannot be provided. Empirical testing based on a literature search may be necessary.
G6423
Gemcitabine hydrochloride
≥98% (HPLC), powder, deoxycytidine analog
Gemcitabine hydrochloride
1 of 1 reviewers received a sample product or took part in a promotion
Synonym(s):
2′-Deoxy-2′,2′-difluorocytidine; dFdC, Gemzar (Lilly), LY-188011, dFdC, dFdCyd
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Select a Size
10 MG
CZK 2,750.00
50 MG
CZK 10,200.00
About This Item
Empirical Formula (Hill Notation):
C9H11F2N3O4 · HCl
CAS Number:
Molecular Weight:
299.66
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Product Name
Gemcitabine hydrochloride, ≥98% (HPLC)
SMILES string
Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
InChI key
OKKDEIYWILRZIA-OSZBKLCCSA-N
InChI
1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
protect from light
solubility
H2O: ≥10 mg/mL
originator
Eli Lilly
storage temp.
room temp
Quality Level
Gene Information
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Related Categories
1 of 4
This Item | Y0000675 | 1288463 | PHR2582 |
|---|---|---|---|
| form powder | form - | form - | form powder |
| assay ≥98% (HPLC) | assay - | assay - | assay - |
| Quality Level 100 | Quality Level - | Quality Level - | Quality Level 300 |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition desiccated, protect from light | storage condition - | storage condition - | storage condition - |
| originator Eli Lilly | originator - | originator - | originator - |
Application
Gemcitabinehydrochloride has been used as a chemotherapeutic agent to study its effects onthe human pancreatic adenocarcinoma cell line[1]It has been used as a chemotherapeutic to study its resistance inpancreatic stellate cells (PSCs)[2]It has also been used to study its effects on patient-derivedxenograft (PDX) organoids.[3]
Biochem/physiol Actions
Gemcitabine is a widely used antineoplastic agent and antimetabolite.
Gemcitabine is a widely used antitumor agents in both clinics and research labs. It is an antineoplastic agent and antimetabolite.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Gemcitabineis a pyrimidine nucleoside analog of deoxycytidine. It exhibits anticancereffects against various cancers.[4]
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yuan Chi et al.
Frontiers in oncology, 11, 671082-671082 (2021-12-07)
Pancreatic cancer is associated with poor prognosis and dismal survival rates. This study aims to investigate roles of lncRNA UCA1-loaded exosomes secreted by pancreatic stellate cells (PSCs) in Gemcitabine (Gem) resistance of pancreatic cancer under hypoxia, which involves the methylation
M Barton-Burke
Cancer nursing, 22(2), 176-183 (1999-04-27)
There have been exciting new developments in anticancer therapy over the past few years. One such therapy uses gemcitabine (GemzarR), an antimetabolite approved in 1996 by the Food and Drug Administration (FDA) for first-line treatment of locally advanced (nonresectable stage
Abdullah Shopit et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 91, 153711-153711 (2021-08-28)
Gemcitabine (GCB) is a first-line chemotherapeutic drug for pancreatic cancer (PCa). However, the resistance begins developing within weeks of chemotherapy. SPINK1 overexpression enhances resistance to chemotherapy. In a recent study, our laboratory established that the oleanolic acid (OA) derivative, K73-03
Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors.
Isabel Romero-Calvo et al.
Molecular cancer research : MCR, 17(1), 70-83 (2018-09-02)
Patient-derived pancreatic ductal adenocarcinoma (PDAC) organoid systems show great promise for understanding the biological underpinnings of disease and advancing therapeutic precision medicine. Despite the increased use of organoids, the fidelity of molecular features, genetic heterogeneity, and drug response to the
Erez Hasnis et al.
Neoplasia (New York, N.Y.), 16(6), 501-510 (2014-06-25)
Weekly gemcitabine therapy is the major treatment offered for patients with pancreatic adenocarcinoma cancer; however, relative resistance of tumor cells to chemotherapy, rapid regrowth, and metastasis are the main causes of death within a year. Recently, the daily continuous administration
Articles
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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welche maximalen Gemcitabinkonzentrationen werden für in-vitro-Modelle in PDAC-Zelllinien empfohlen? Die Angaben in der Literatur sind teilweise stark voneinander abweichend
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Wie können Aliquotes (in NaCl) am besten gelagert werden? Wäre eine Lagerung bei -20°C bedenkenlos über einen längeren Zeitraum möglich?
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This product can be stored in aliquots and frozen at -20°C. Stock solutions are stable for up to 6 months at -20°C.
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