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Merck

G9518

Gemfibrozil

PPARα and PPARγ agonist, powder

Synonym(s):

2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid, 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid, 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

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5 G

CZK 2,460.00

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CZK 9,630.00

CZK 2,460.00

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About This Item

Empirical Formula (Hill Notation):
C15H22O3
CAS Number:
25812-30-0
Molecular Weight:
250.33
NACRES:
NA.77
PubChem Substance ID:
24895377
UNSPSC Code:
12352200
EC Number:
247-280-2
MDL number:
MFCD00079335

Key Documents

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Product Name

Gemfibrozil,

InChI

1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChI key

HEMJJKBWTPKOJG-UHFFFAOYSA-N

SMILES string

Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1

form

powder

Quality Level

100

Gene Information

human ... PPARA(5465)

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This Item
PHR12861288500Y0000514
Gemfibrozil

Sigma-Aldrich

G9518

Gemfibrozil

Gemfibrozil Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1286

Gemfibrozil

Gemfibrozil United States Pharmacopeia (USP) Reference Standard

USP

1288500

Gemfibrozil

Gemfibrozil for system suitability European Pharmacopoeia (EP) Reference Standard

Y0000514

Gemfibrozil for system suitability

form

powder

form

-

form

-

form

-

Quality Level

100

Quality Level

300

Quality Level

-

Quality Level

-

Gene Information

human ... PPARA(5465)

Gene Information

human ... PPARA(5465)

Gene Information

human ... PPARA(5465)

Gene Information

human ... PPARA(5465)

Application

Gemfibrozil has been used to to study its effects on cell cycle progression in yeast.[1] It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.[2]

Biochem/physiol Actions

Gemfibrozil selectively increases Apolipoprotein A-I levels.[3] In yeast cells, application of gemfibrozil delays the start of DNA replication.[1] It is used as a therapeutic agent for dyslipidemia.[2]

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

General description

Gemfibrozil is a fibric acid derivative and a hypolipidemic drug. Gemfibrozil serves as a ligand for PPARα (peroxisome proliferator-activated receptor α).[2][4]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG9003
BCBP4924
BCBP4924V
030M1424V
SLBD3802V

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Izabela Zakrocka et al.
Life (Basel, Switzerland), 13(11) (2023-11-25)
Kidney dysfunction significantly increases the cardiovascular risk, even in cases of minor functional declines. Hypertriglyceridemia is the most common lipid abnormality reported in patients with kidney disorders. PPAR-α (peroxisome proliferator-activated receptor-α) agonists called fibrates are the main agents used to
Katerina Cizkova et al.
Lipids in health and disease, 15(1), 164-164 (2016-09-24)
Fibrates are widely used hypolipidemic drugs, which serve as ligand of peroxisome proliferator-activated receptor α (PPARα). Recently, they have also been considered as potential anticancer agents. We studied effect of fibrates treatment on cell proliferation, expression of CYP2J2 and concomitant
Benjamin Allcock et al.
Cells, 12(19) (2023-10-13)
It is widely recognised that cells respond to their microenvironment, which has implications for cell culture practices. Growth cues provided by 2D cell culture substrates are far removed from native 3D tissue structure in vivo. Geometry is one of many
Ana Maria Sierra Villar et al.
International journal of pharmaceutics, 431(1-2), 161-175 (2012-04-14)
Self-nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the
Manthena V S Varma et al.
Pharmaceutical research, 29(10), 2860-2873 (2012-05-29)
To develop physiologically based pharmacokinetic (PBPK) model to predict the pharmacokinetics and drug-drug interactions (DDI) of pravastatin, using the in vitro transport parameters. In vitro hepatic sinusoidal active uptake, passive diffusion and canalicular efflux intrinsic clearance values were determined using
View All Related Papers

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