P215

PD 98,059

Name: PD 98,059
Brand: SIGMA
Price: 3250 CZK

MAPKK inhibitor, solid

Synonym(s):

2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₃NO₃

CAS Number:

167869-21-8

Molecular Weight:

267.28

UNSPSC Code:

12352200

PubChem Substance ID:

24278666

NACRES:

NA.77

MDL number:

MFCD00671789

Key Documents

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Product Name

PD 98,059, solid

SMILES string

COc1cccc(c1N)C2=CC(=O)c3ccccc3O2

InChI

1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChI key

QFWCYNPOPKQOKV-UHFFFAOYSA-N

form

solid

color

yellow

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Gene Information

human ... MAP2K1(5604), MAP2K2(5605), MAP2K3(5606), MAP2K4(6416), MAP2K5(5607), MAP2K6(5608), MAP2K7(5609), MAP3K1(4214), RAF1(5894)

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Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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Show Differences

1 of 4

This Item	SML0947	513000	SML2365
Sigma-Aldrich P215 PD 98,059	Sigma-Aldrich SML0947 YN1	Sigma-Aldrich 513000 PD 98059	Sigma-Aldrich SML2365 Phenprocoumon
form solid	form powder	form solid	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 10 mg/mL, clear	solubility DMSO: 10 mg/mL, clear	solubility methanol: 0.7 mg/mL, DMSO: 20 mg/mL	solubility DMSO: 2 mg/mL, clear
color yellow	color white to beige	color pale yellow	color white to beige
Gene Information human ... MAP2K1(5604), MAP2K2(5605), MAP2K3(5606), MAP2K4(6416), MAP2K5(5607), MAP2K6(5608), MAP2K7(5609), MAP3K1(4214), RAF1(5894)	Gene Information -	Gene Information -	Gene Information -

Application

PD 98,059 has been used:

in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors[1]
in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown[2]
in culture medium for cell migration assay[3]

Biochem/physiol Actions

PD 98,059 is a flavonoid[4] and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock.[5] It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.[6]

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold with permission of Warner Lambert Company.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Sepsis: Advances in Research and Treatment: 2011 Edition, 38-38 (2012)

PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase

Reiners JJ, et al.

Molecular Pharmacology, 53(3), 438-445 (1998)

Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing

Chen J

Cellular Physiology and Biochemistry, 39(6), 2262-2274 (2016)

D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression

Zeng C, et al.

Journal of Hypertension, 27(5), 1033-1033 (2009)

Extracellular Matrix Proteins: Advances in Research and Application (2012)

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PD 98,059