RAB0849

Mouse Tnfsf10 / Tumor Necrosis Factor Ligand Superfamily Member 10 ELISA Kit

for serum, plasma and cell culture supernatants

• NACRES: NA.32
• UNSPSC Code: 41116158
• Gene information: mouse ... Tnfsf10(22035)
• Input: sample type plasma; sample type serum; sample type cell culture supernatant(s)
• Species reactivity: mouse
• Storage temp.: −20°C
• Shipped in: wet ice

Properties

• species reactivity: mouse
• packaging: kit of 96 wells (12 strips x 8 wells)
• technique(s): ELISA: suitable
• input: sample type plasma; sample type serum; sample type cell culture supernatant(s)
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 2 pg/mL; standard curve range: 2.46-600 pg/mL
• detection method: colorimetric
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... Tnfsf10(22035)

Description

General description

The antibody pair provided in this kit recognizes mouse TRAIL/TNFSF10.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) activates the extrinsic apoptotic pathway by binding death receptors (DR)-4 and 5. In addition to DR 4 and 5, TRAIL activates several other receptors such as decoy receptor (DcR)1, DcR2 and a soluble receptor called osteoprotegerin. TRAIL plays a vital role in the inhibition of autoimmune inflammation and cell cycle progression. TRAIL selectively kills tumor cells without damaging normal tissues and therefore, it might act as a tumor-selective anticancer agent. TRAIL-induced apoptosis is involved in various cellular processes including activation-induced cell death, homeostasis, intrathymic negative selection, autoimmunity suppression, and immune surveillance. Repeated dosage of recombinant soluble TRAIL triggers apoptosis, inhibits tumor progression, and increases viability of mice suffering from cancer.

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

• RABTMB3

  ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)

  SDS
• RABSTOP3

  ELISA Stop Solution (Item I)

  SDS
• RABELADA

  ELISA 1X Assay/Sample Diluent Buffer A (Item D1)

  SDS
• RABELADB

  ELISA 5X Assay/Sample Diluent Buffer B (Item E1)

  SDS
• RABWASH4

  20X Wash Buffer (Item B)

  SDS

Safety Information

• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• Pictograms: GHS08
• Signal Word: Danger
• Hazard Codes: H334
• Storage Class: 10 - Combustible liquids
• Precautionary Statements: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1