SAB2900202

Anti-CX3CR1 antibody produced in rabbit

Name: Anti-CX3CR1 antibody produced in rabbit
Brand: SIGMA
Price: 17800 CZK

affinity isolated antibody, buffered aqueous solution

Synonym(s):

beta chemokine receptor-like 1, chemokine c-x3-c receptor 1, cmkbrl1, cmkdr1, fkn receptor

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50 μG

CZK 17,800.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

UniProt accession no.

P49238

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CX3CR1(1524)

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This Item	SAB3500204	HPA030311	HPA077743
Sigma-Aldrich SAB2900202 Anti-CX3CR1 antibody produced in rabbit	Sigma-Aldrich SAB3500204 Anti-CX3CR1 antibody produced in rabbit	Sigma-Aldrich HPA030311 Anti-CX3CR1 antibody produced in rabbit	Sigma-Aldrich HPA077743 Anti-CX3CR1 antibody produced in rabbit
Quality Level 100	Quality Level 100	Quality Level -	Quality Level -
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable	technique(s) flow cytometry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable	technique(s) immunofluorescence: 0.25-2 μg/mL	technique(s) immunofluorescence: 0.25-2 μg/mL

General description

C-X3-C motif chemokine receptor 1 (CX3CR1) is a transmembrane G-coupled chemokine receptor of its ligand, fractalkine. This receptor is expressed on epithelial cells, smooth muscle cells, microglia, monocytic cells and natural killer cells. The gene encoding CX3CR1 is localized on human chromosome 3p21.3 and has five exons.

Immunogen

Synthetic 19 amino acid peptide from 3rd extracellular domain of human CX3CR1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey (95%); Marmoset, Mouse, Panda (84%).

Biochem/physiol Actions

C-X3-C motif chemokine receptor 1 (CX3CR1) may be linked to the development of macular degeneration. It also acts as a receptor aiding viral entry.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate-buffered saline containing less than 0.1% sodium azide.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

37647

22245

2052A

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CX3CR1 polymorphisms and the risk of age-related macular degeneration.

Ma B

International Journal of Clinical and Experimental Pathology, 8(8), 9592-9596 (2015)

Fractalkine/CX3CR1 induces apoptosis resistance and proliferation through the activation of the AKT/NF-?B cascade in pancreatic cancer cells.

Wang H

Cell Biochemistry and Function, 35(6), 315-326 (2017)

CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells.

Chirkova T

The Journal of General Virology, 96(9), 2543-2556 (2015)

CX3CR1 Acts as a Protective Biomarker in the Tumor Microenvironment of Colorectal Cancer.

Yuanyi Yue et al.

Frontiers in immunology, 12, 758040-758040 (2022-02-11)

The tumor microenvironment (TME) plays an important role in the pathogenesis of many cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) and identify possible prognostic biomarkers. The gene expression profiles and clinical data of 464

SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming.

Chien-Ting Wu et al.

Cell, 186(1), 112-130 (2022-12-30)

How SARS-CoV-2 penetrates the airway barrier of mucus and periciliary mucins to infect nasal epithelium remains unclear. Using primary nasal epithelial organoid cultures, we found that the virus attaches to motile cilia via the ACE2 receptor. SARS-CoV-2 traverses the mucus

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