MABS2044

Anti-HPd2 Antibody, clone DHIC3-5H10

clone DHIC3-5H10, from mouse

• Synonym(e): Human pancreatics duct cells
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: DHIC3-5H10, monoclonal
• Speziesreaktivität: human
• Verpackung: antibody small pack of 25 μg
• Methode(n): immunofluorescence: suitable; immunohistochemistry: suitable (paraffin)
• Isotyp: IgMκ
• Posttranslationale Modifikation Target: unmodified

Beschreibung

Allgemeine Beschreibung

Pancreas performs both the endocrine and the exocrine function. The bulk of pancreas is composed of exocrine cells that produce digestion enzymes which are released into ducts to be emptied into the duodenum. The endocrine pancreas is composed of islets of Langerhans that produce hormones. At least five distinct endocrine cell types have been identified in the endocrine pancreas, each producing a different hormone. Beta cells produce insulin, which is considered as an anabolic hormone and regulates blood glucose levels and is also involved in fat and protein synthesis. Alpha cells produce glucagon that acts when blood glucose levels are low. Ductal cells of pancreas form the epithelial lining of the branched tubes that deliver digestive enzymes into the duodenum. They also secrete bicarbonate to neutralize acidic contents coming in from stomach. Duct cells may contribute up to 10% of all pancreatic cells. Acinar cells function as a unit of the exocrine pancreas and they synthesize, store, and secrete digestive enzymes (lipase, alpha amylase, trypsin, and chymotrypsin), which under normal physiological conditions are activated only after reaching the duodenum. Premature activation of these enzymes within pancreatic acinar cells can lead to acute pancreatitis. Clone DCHI3-5H10 can be used to detect duct cells in human pancreatic tissue. (Ref.: Dorrell, C., et al. (2008). Stem Cell Research (2008). 1(3); 183-194; Grapin-Botton, A (2005). Int. J. Biochem. Cell Biol. 37(3); 504-510; Leung, PS (2006). Int. J. Biochem. Cell Biol. 38(7); 1024-1030).

Immunogen

Trypsin-dissociated human pancreatic duct cells.

Anwendung

Research Category
Zelluläre Signaltransduktion

Anti-HPd2, clone DHIC3-5H10, Cat. No. MABS2044, is a mouse monoclonal antibody that detects Duct2 cells of pancreas and has been tested for use in Immunofluorescence and Immunohistochemistry (Paraffin).

Immunofluorescence Analysis: A representative lot detected HPd2 in Immunofluorescence applications (Dorrell, C., et. al. (2008). Stem Cell Res. 1(3):183-94).

Biochem./physiol. Wirkung

Clone DCHI3-5H10 specifically detects human pancreatic duct cells.

Physikalische Form

Format: Purified

Purified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.

Angaben zur Herstellung

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Evaluated by Immunohistochemistry (Paraffin) in human pancreatic tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected HPd2 in human pancreatic tissue sections.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable