03-0145-00

SMC^® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit

Name: SMC<SUP>®</SUP> Amyloid Beta 1-40 High Sensitivity Immunoassay Kit
Brand: MM

Synonym(s):

Abeta 1-40 immunoassay kit, Abeta 40 Single Molecule Counting kit, Abeta 40 immunoassay kit, Abeta 40 ultra-sensitive immunoassay

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About This Item

UNSPSC Code:

12161503

eCl@ss:

32161000

NACRES:

NA.84

Key Documents

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Quality Level

200

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This Item	03-0146-00	03-0185-00	EZHS40
Millipore 03-0145-00 SMC^® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit	Millipore 03-0146-00 SMC^® Amyloid Beta 42 High Sensitivity Immunoassay Kit	Millipore 03-0185-00 SMC^® Human Total Tau High Sensitivity Immunoassay Kit	Millipore EZHS40 High Sensitivity Human Amyloid β40 ELISA
technique(s) ELISA: suitable, single molecule counting: suitable	technique(s) ELISA: suitable, single molecule counting: suitable	technique(s) -	technique(s) ELISA: suitable
manufacturer/tradename SMC^®	manufacturer/tradename SMC^®	manufacturer/tradename SMC^®	manufacturer/tradename -
assay range sensitivity: 5.86 pg/mL (lower limit of quantification)	assay range sensitivity: 0.98 pg/mL (lower limit of quantification), inter-assay cv: <20% intra-assay cv: <15% standard curve range: 0.24-250 pg/mL	assay range sensitivity: 4.69 pg/mL ((lower limit of quantification)), inter-assay cv: ≤4% intra-assay cv: ≤8% (Intra-assay CV n=5; Inter-assay n=3)	assay range sensitivity: 6.0 pg/mL (50 μl sample size), standard curve range: 16-500 pg/mL
Quality Level 200	Quality Level 200	Quality Level -	Quality Level 200

General description

Amyloid Beta 1-40 (Aβ1-40) is a peptide that arises from the proteolytic cleavage of the amyloid precursor protein (APP), a transmembrane protein thought to be involved in neuronal development and function. Aβ1-40 is one of the most common isoforms generated from APP, alongside Aβ1-42, which is more toxic and associated with the formation of amyloid plaques in neurodegenerative diseases.
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.

Application

Neuroscience/Neurological Disorders/Signaling

Biochem/physiol Actions

Although Amyloid Beta 40 was detectable in mouse and rat samples, the assay has not been verified for these species.

Features and Benefits

Exceptional Sensitivity: Detects Amyloid Beta 1-40 at femtogram levels, significantly outperforming conventional ELISA methods.
Wider Dynamic Range: Minimizes background interference to deliver clearer signals and improved assay reliability.
Optimized Workflow Efficiency: Automation-compatible reagents streamline lab processes and reduce manual intervention.
Experienced Technical Support: Supported by skilled field scientists and technical teams with expertise in SMC^® assays.

Packaging

96 well assay

Analysis Note

Neuroscience Neurological Disorders Neurodegenerative Diseases Alzheimer′s Disease

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

GHS06,GHS08

Signal Word

Danger

Hazard Statements

H302 + H332,H311,H319,H360FD,H412

Precautionary Statements

P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Role of Physical Fitness in Cognitive-Related Biomarkers in Persons at Genetic Risk of Familial Alzheimer's Disease.

Chia-Liang Tsai et al.

Journal of clinical medicine, 8(10) (2019-10-09)

Nondemented people with a family history of Alzheimer's disease (ADFH) and the ApoE-4 allele have been demonstrated to show a trend for a higher probability of cognitive decline and aberrant levels of cognitive-related biomarkers. However, the potential interactive effects on

Protocols

Protein Determination by the Warburg-Christian Method

To determine protein content, the Warburg-Christian method refers to measuring protein samples at 280 nm using a spectrophotometer.

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