WH0005338M1

Monoclonal Anti-PLD2 antibody produced in mouse

Name: Monoclonal Anti-PLD2 antibody produced in mouse
Brand: SIGMA
Price: 434 EUR
Availability: InStock

clone 1C5, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-phospholipase D2

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100 μG

€434.00

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A recombinant, preservative-free antibody is available for your target. Try ZRB1629

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Key Documents

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Product Name

Monoclonal Anti-PLD2 antibody produced in mouse, clone 1C5, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1C5, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

GenBank accession no.

BC015033

UniProt accession no.

O14939

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

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This Item	SAB2102984	WH0005337M1	SAB1404216
Sigma-Aldrich WH0005338M1 Monoclonal Anti-PLD2 antibody produced in mouse	Sigma-Aldrich SAB2102984 Anti-PLD2 antibody produced in rabbit	Sigma-Aldrich WH0005337M1 Monoclonal Anti-PLD1 antibody produced in mouse	Sigma-Aldrich SAB1404216 Monoclonal Anti-PLD1, (C-terminal) antibody produced in mouse
clone 1C5, monoclonal	clone polyclonal	clone 2F3, monoclonal	clone 10H2, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source rabbit	biological source mouse	biological source mouse
Gene Information human ... PLD2(5338)	Gene Information human ... PLD2(5338)	Gene Information human ... PLD1(5337)	Gene Information human ... PLD1(5337)
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
species reactivity human	species reactivity human, bovine	species reactivity human	species reactivity human

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM

Immunogen

PLD2 (AAH15033, 834 a.a. ~ 933 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
LRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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Certificates of Analysis (COA)

Lot/Batch Number

DB261-1C5

08077-1C5

06237-1C5

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Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration.

Alba Diz-Muñoz et al.

PLoS biology, 14(6), e1002474-e1002474 (2016-06-10)

For efficient polarity and migration, cells need to regulate the magnitude and spatial distribution of actin assembly. This process is coordinated by reciprocal interactions between the actin cytoskeleton and mechanical forces. Actin polymerization-based protrusion increases tension in the plasma membrane

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