14-198

MAP Kinase 2/Erk2 Protein, inactive, Mouse, 50 g

Name: MAP Kinase 2/Erk2 Protein, inactive, Mouse, 50 g
Brand: MM
Price: 4520 DKK

Unactive, recombinant full-length mouse p42 MAP Kinase 2/Erk2 fused with GST at the N terminus, for use in Kinase Assays.

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50 μG

4.520,00 kr.

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About This Item

UNSPSC Code:

12352202

eCl@ss:

32160405

NACRES:

NA.41

Key Documents

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biological source

mouse

Quality Level

100

recombinant

expressed in E. coli

mol wt

M_w 67.8 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_011949.3

UniProt accession no.

P63085

shipped in

dry ice

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This Item	14-536	14-173-M	14-515
Sigma-Aldrich 14-198 MAP Kinase 2/Erk2 Protein, inactive, Mouse, 50 g	Sigma-Aldrich 14-536 MAP Kinase 2/Erk2 Protein, inactive, Human, 50 g	Sigma-Aldrich 14-173-M MAP Kinase 2/Erk2 Protein, active, mouse, 10 µg	Sigma-Aldrich 14-515 MAP Kinase 1/Erk1 Protein, inactive, 50 g
biological source mouse	biological source human	biological source mouse	biological source human
technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
UniProt accession no. P63085	UniProt accession no. P28482	UniProt accession no. P63085	UniProt accession no. P28482
mol wt M_w 67.8 kDa	mol wt M_w 67.8 kDa	mol wt M_w 67.8 kDa	mol wt M_w 70 kDa
shipped in dry ice	shipped in dry ice	shipped in -	shipped in dry ice

General description

Product Source: expressed in E coli

Recombinant full-length mouse p42 MAP Kinase 2/Erk2 fused with GST at the N terminus

Analysis Note

routinely evaluated by phosphorylation of MBP (Catalog # 13-104) substrate in vitro.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H317

Precautionary Statements

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.

Tian-Rui Xu et al.

The Biochemical journal, 413(1), 51-60 (2008-04-26)

FRET (fluorescence resonance energy transfer) and co-immunoprecipitation studies confirmed the capacity of beta-arrestin 2 to self-associate. Amino acids potentially involved in direct protein-protein interaction were identified via combinations of spot-immobilized peptide arrays and mapping of surface exposure. Among potential key

Signal transduction inhibitors in cellular function.

Maofu Fu et al.

Methods in molecular biology (Clifton, N.J.), 284, 15-36 (2004-06-03)

Signal transduction pathways mediate cell-cell interactions and integrate signals from the extracellular environment through specific receptors at the cell membrane. They play a pivotal role in regulating cellular growth and differentiation and in mediating many physiological and pathological processes, such

Contractile activity stimulates the c-Jun NH2-terminal kinase pathway in rat skeletal muscle.

D Aronson et al.

The Journal of biological chemistry, 272(41), 25636-25640 (1997-11-05)

Contractile activity plays a critical role in the regulation of gene transcription in skeletal muscle, which in turn determines muscle functional capabilities. However, little is known about the molecular signaling mechanisms that convert contractile activity into gene regulatory responses in

Raf-MEK-Erk cascade in anoikis is controlled by Rac1 and Cdc42 via Akt.

O Zugasti et al.

Molecular and cellular biology, 21(19), 6706-6717 (2001-09-05)

Signals from the extracellular matrix are essential for the survival of many cell types. Dominant-negative mutants of two members of Rho family GTPases, Rac1 and Cdc42, mimic the loss of anchorage in primary mouse fibroblasts and are potent inducers of

All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation.

Shawna D Persaud et al.

Scientific reports, 6, 22396-22396 (2016-03-05)

All trans retinoic acid (atRA) is one of the most potent therapeutic agents, but extensive toxicity caused by nuclear RA receptors (RARs) limits its clinical application in treating cancer. AtRA also exerts non-genomic activities for which the mechanism remains poorly

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