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Merck

27487

Citric acid

BioUltra, anhydrous, ≥99.5% (T)

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About This Item

Linear Formula:
HOC(COOH)(CH2COOH)2
CAS Number:
77-92-9
Molecular Weight:
192.12
NACRES:
NA.25
PubChem Substance ID:
57648248
eCl@ss:
39021801
UNSPSC Code:
12161700
EC Number:
201-069-1
MDL number:
MFCD00011669
Beilstein/REAXYS Number:
782061

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Product Name

Citric acid, BioUltra, anhydrous, ≥99.5% (T)

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

grade

biotech. grade

product line

BioUltra

assay

≥99.5% (T)

form

powder or crystals

expl. lim.

8 %, 65 °F

technique(s)

cell culture | hybridoma: suitable

impurities

insoluble matter, passes filter test

ign. residue

≤0.05% (as SO4)

loss

≤0.5% loss on drying, 110 °C

pH

1.0-2.0 (25 °C, 1 M in H2O)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

mp

153-159 °C (lit.)

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤5 mg/kg
oxalate (C2O42-): ≤0.05%
phosphate (PO43-): ≤5 mg/kg
sulfate (SO42-): ≤20 mg/kg
tartrate (C4H4O62-): ≤0.20%

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λmax

260 nm (Amax: ≤0.20)
280 nm (Amax: ≤0.10)

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: 0.20
λ: 280 nm Amax: 0.10

Quality Level

200

Gene Information

human ... SRC(6714)

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Show Differences

1 of 4

This Item
251275C2404W230618
Citric acid BioUltra, anhydrous, ≥99.5% (T)

Sigma-Aldrich

27487

Citric acid

Citric acid ACS reagent, ≥99.5%

Sigma-Aldrich

251275

Citric acid

Citric acid anhydrous, suitable for cell culture, suitable for plant cell culture

Sigma-Aldrich

C2404

Citric acid

Citric acid ≥99.5%, FCC, FG

Sigma-Aldrich

W230618

Citric acid

assay

≥99.5% (T)

assay

≥99.5%

assay

≥97% (GC)

assay

≥99.5%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

400

form

powder or crystals

form

crystals

form

powder

form

powder or granules

pH

1.0-2.0 (25 °C, 1 M in H2O)

pH

-

pH

1.8 (25 °C, 50 g/L)

pH

-

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

-

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless

solubility

water: 383 g/L at 25 °C

cation traces

Al: ≤5 mg/kg, Ba: ≤5 mg/kg, Ca: ≤10 mg/kg, Co: ≤5 mg/kg, Cu: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mo: ≤5 mg/kg, Ni: ≤5 mg/kg, Sr: ≤5 mg/kg, As: ≤0.1 mg/kg, Cd: ≤5 mg/kg, Fe: ≤5 mg/kg, Mn: ≤5 mg/kg, Pb: ≤5 mg/kg, Bi: ≤5 mg/kg, Li: ≤5 mg/kg, Zn: ≤5 mg/kg, Cr: ≤5 mg/kg, Na: ≤50 mg/kg

cation traces

Fe: ≤3 ppm, Pb: ≤2 ppm

cation traces

-

cation traces

As: ≤3.0 ppm, Cd: ≤1.0 ppm, Hg: ≤1.0 ppm, Pb: ≤0.5 ppm

Application


  • Enhancing soil microbiomes: Citric acid has been applied to modify soil bacterial communities in saline mudflats, demonstrating its utility in environmental biotechnology for sustainable ecosystem management (Liu et al., 2024).

  • Biodegradable packaging in food industry: In food chemistry, citric acid is used in conjunction with polyvinyl alcohol for developing antimicrobial packaging, highlighting its potential in food safety and preservation (Xu et al., 2024).

  • Nanomaterial synthesis for engineering applications: Citric acid serves as a key component in the eco-friendly synthesis of hybrid nanomaterials for supercapacitors, underpinning its role in advancing materials science and engineering (Teixeira et al., 2024).

  • Environmental science and pollution control: Research utilizes citric acid to study the co-transport of pharmaceuticals and nanoparticles in environmental systems, aiding in the understanding of contaminant dynamics and mitigation strategies (Cui et al., 2024).

  • Food science and technology: Citric acid is employed in the formulation of vegan gummies, indicating its versatility in food product development and its impact on textural properties (Rawat et al., 2024).

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to the US EPA′s Federal Insecticide Fungicide and Rodenticide Act, the European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR), and others.

General description

Citric acid is a buffer component for triple-column amino acid analysis.[1] It is an optimal buffer for dissociation of radioiodinated antibodies from viable murine tumor cells.[2]

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN1584
BCCM5331
BCCL7180
BCCK3439
BCCH7922

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R Ehrlich et al.
Journal of immunological methods, 26(4), 345-353 (1979-01-01)
Several low pH buffers were used in order to dissociate radioiodinated antibodies from sensitized living tumor cells. Three buffers were further tested for their dissociation abilities under different conditions of time and temperature, and for their influence on the eluted
T N Ferraro et al.
Analytical biochemistry, 143(1), 82-94 (1984-11-15)
A highly resolving triple-column amino acid analyzer with fluorometric detection is described. The reliability of this technique was evaluated and it was used in a baseline investigation of amino acids and related compounds in human cerebrospinal fluid (CSF). The procedure
Felix Schiele et al.
mAbs, 7(5), 871-880 (2015-06-06)
Novel oral anticoagulants are effective and safe alternatives to vitamin-K antagonists for anticoagulation therapy. However, anticoagulation therapy in general is associated with an elevated risk of bleeding. Idarucizumab is a reversal agent for the direct thrombin inhibitor, dabigatran etexilate (Pradaxa®)
Wayne B Batchelor et al.
Circulation, 106(12), 1470-1476 (2002-09-18)
The relative anti-aggregatory effects of currently prescribed platelet glycoprotein IIb/IIIa receptor antagonists during and after percutaneous coronary intervention for acute coronary syndromes have not been established. We randomized 70 acute coronary syndrome patients undergoing percutaneous coronary intervention to receive abciximab
Konrad Hoetzenecker et al.
European heart journal, 36(11), 676-685 (2013-01-17)
Supernatants of serum-free cultured mononuclear cells (MNC) contain a mix of immunomodulating factors (secretome), which have been shown to attenuate detrimental inflammatory responses following myocardial ischaemia. Inflammatory dilated cardiomyopathy (iDCM) is a common cause of heart failure in young patients.
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