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Merck

394882

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

>97%

Sinónimos:

MTBSTFA

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Fórmula lineal:
CF3CON(CH3)Si(CH3)2C(CH3)3
Número CAS:
Peso molecular:
241.33
UNSPSC Code:
12352001
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3606546

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Nombre del producto

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, >97%

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI key

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

grade

derivatization grade

assay

>97%

form

liquid

refractive index

n20/D 1.402 (lit.)

bp

172-175 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

functional group

amine
fluoro

storage temp.

2-8°C

Quality Level

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Este artículo
375934M0789155195
assay

>97%

assay

≥95%

assay

≥97.0% (GC)

assay

≥99%

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

refractive index

n20/D 1.402 (lit.)

refractive index

-

refractive index

n20/D 1.346 (lit.)

refractive index

n20/D 1.384 (lit.)

bp

172-175 °C (lit.)

bp

-

bp

121-122 °C (lit.)

bp

45-50 °C/14 mmHg (lit.)

form

liquid

form

liquid

form

liquid

form

liquid

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

Application

N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) can be used:
  • As a derivatizing agent in the GC-MS analysis of hydroxylated fluorenes and in the GC analysis of amino acids. [1]
  • As an efficient silylating agent for different alcohols, thiols, phenols, carboxylic acids, amines, and amides.
  • To functionalize multi-walled carbon nanotubes (MWCNTs) with polar groups.[2][3][4]
MTBSTFA is reportedly much less moisture-sensitive than other silylating reagents used for GLC derivatization.

General description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a highly reactive silylating reagent commonly used for silyation of carboxylic acids, alcohols, amines, and thiols. It is also used as a protection, deprotection reagent. [5]

pictograms

Flame

signalword

Warning

hcodes

Hazard Classifications

Flam. Liq. 3

Clase de almacenamiento

3 - Flammable liquids

wgk

WGK 3

flash_point_f

113.0 °F - closed cup

flash_point_c

45 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Certificados de análisis (COA)

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Visite la Librería de documentos

Evaluating MTBSTFA derivatization reagents for measuring naphthenic acids by gas chromatography-mass spectrometry
Rozlyn YF,et al.
Analytical Methods, 2, 765-770 (2010)
Silylation of multi-walled carbon nanotubes
Aizawa M, et al.
Chemical Physics Letters, 368(1-2), 121-124 (2003)
Determination of β-blockers and β-agonists using gas chromatography and gas chromatography-mass spectrometry-a comparative study of the derivatization step
Caban M, et al.
Journal of Chromatography A, 1218(44), 8110-8122 (2011)
High-throughput analysis of selected urinary hydroxy polycyclic aromatic hydrocarbons by an innovative automated solid-phase microextraction
Stefano D,et al.
Molecules (Basel), 23, 1869-1869 (2018)
Two stage derivatization with N-(tert.-butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) and N-methyl-bis-(trifluoroacetamide)(MBTFA) for the gas-chromatographic analysis of OH-, SH-and NH-compounds
Schoene K, et al.
Fresenius Journal of Analytical Chemistry, 348(5-6), 364-370 (1994)

Artículos

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Preguntas

1–2 de 2 Preguntas  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 respuesta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 respuesta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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