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Merck

324517

4EGI-1

≥98% (sum of two isomers, HPLC), eIF4E inhibitor, solid

Sinónimos:

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I

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Fórmula empírica (notación de Hill):
C18H12Cl2N4O4S
Número CAS:
315706-13-9
Peso molecular:
451.28
Número MDL:
MFCD10565943
Código UNSPSC:
12352200
NACRES:
NA.77

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Nombre del producto

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Nivel de calidad

100

Ensayo

≥98% (sum of two isomers, HPLC)

Formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

yellow

solubilidad

DMSO: 100 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

InChI

1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14+

Clave InChI

KFRKRECSIYXARE-HYARGMPZSA-N

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Este artículo
324519217505475956
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 The eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, also referenced under CAS 315706-13-9, controls the biological activity of eIF4E/eIF4G interaction. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Sigma-Aldrich

324517

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 InSolution, ≥95%, reversibly binds eukaryotic translation initiation factor 4E

Sigma-Aldrich

324519

eIF4E/eIF4G Interaction Inhibitor, 4EGI-1

CBP-CREB Interaction Inhibitor The CBP-CREB Interaction Inhibitor, also referenced under CAS 92-78-4, controls the biological activity of CBP-CREB.

Sigma-Aldrich

217505

CBP-CREB Interaction Inhibitor

c-Myc Inhibitor The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.

Sigma-Aldrich

475956

c-Myc Inhibitor

form

solid

form

liquid

form

solid

form

solid

assay

≥98% (sum of two isomers, HPLC)

assay

≥95% (sum of two isomers, HPLC)

assay

≥97% (HPLC)

assay

≥95% (sum of two isomers, HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

−70°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

Descripción general

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).

Envase

Packaged under inert gas

Nota de preparación

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Moerke, N. J., et al. 2007. Cell128, 257.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Toxicity: Harmful (C)

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

677.1 °F - (calculated)

Punto de inflamabilidad (°C)

358.4 °C - (calculated)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Aging cell, 21(9), e13685-e13685 (2022-08-06)
Glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) hydrolyzes inositol phosphate linkages in proteins anchored to the cell membrane. Mice overexpressing GPLD1 show enhanced neurogenesis and cognition. Snell dwarf (DW) and growth hormone receptor knockout (GKO) mice show delays in age-dependent cognitive decline. We
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In ribosomopathies, perturbed expression of ribosome components leads to tissue-specific phenotypes. What accounts for such tissue-selective manifestations as a result of mutations in the ribosome, a ubiquitous cellular machine, has remained a mystery. Combining mouse genetics and in vivo ribosome profiling
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Cells, 10(8) (2021-08-28)
Translation initiation factor 2B (eIF2B) is a master regulator of global protein synthesis in all cell types. The mild genetic Eif2b5(R132H) mutation causes a slight reduction in eIF2B enzymatic activity which leads to abnormal composition of mitochondrial electron transfer chain
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Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. Expansion segments (ESs) consist of multitudes of tentacle-like rRNA structures extending from the core ribosome in eukaryotes. ESs are remarkably variable

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