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Merck

PHR1237

Supelco

Colecalciferol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

(+)-Vitamina D3, 7-deshidrocolesterol activado, Activado, 7-deshidrocolesterol, Calciol

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500 MG
123,00 €

123,00 €


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500 MG
123,00 €

About This Item

Fórmula empírica (notación de Hill):
C27H44O
Número de CAS:
Peso molecular:
384.64
Beilstein:
2339331
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

123,00 €


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grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

Agency

traceable to BP 787
traceable to Ph. Eur. C2100000
traceable to USP 1131009

familia API

cholecalciferol

Formulario

solid

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

83-86 °C (lit.)

aplicaciones

food and beverages

Formato

neat

temp. de almacenamiento

-10 to -25°C

cadena SMILES

CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C

InChI

1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

Clave InChI

QYSXJUFSXHHAJI-YRZJJWOYSA-N

Información sobre el gen

human ... VDR(7421)

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cholecalciferol (vitamin D3) is a fat-soluble vitamin that manifests skeletal and extra-skeletal effects. The skeletal effects augment the bone health whereas the extra-skeletal effects concern the immune system, the cognition, the cardiovascular system, etc.[1]

Aplicación

Cholecalciferol (Vitamin D3) may be used as a pharmaceutical reference standard for the determination of the analyte in food, feeds,[2] serum samples[3] and pharmaceutical formulations[4][2][3] by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

La Vitamina D actúa a través de un receptor que forma parte de la superfamilia del factor de transcripción dependiente del ligando. Modula la proliferación y diferenciación de las células normales y cancerosas. Tiene efectos contrarios a la proliferación y desarrollo de metástasis en células de cáncer de mama, colon y próstata. Receptores activados de vitamina D en el intestino y los huesos mantienen la absorción de calcio y la homeostasis.
La vitamina D actúa a través de un receptor que modula la proliferación y la diferenciación tanto de las células sanas como de las cancerosas.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC0270 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Skull and crossbonesHealth hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Is supercritical fluid chromatography hyphenated to mass spectrometry suitable for the quality control of vitamin D3 oily formulations?
Andri B, et al.
Journal of Chromatography A, 1515(5-6), 209-217 (2017)
Simultaneous microemulsion liquid chromatographic analysis of fat-soluble vitamins in pharmaceutical formulations: optimization using genetic algorithm
Momenbeik F, et al.
Journal of Chromatography A, 1217(24), 3770-3773 (2010)
High-performance liquid chromatographic determination of vitamin D in foods, feeds and pharmaceuticals by successive use of reversed-phase and straight-phase columns
TAKEUCHI A, et al.
Journal of nutritional science and vitaminology, 30(1), 11-25 (1984)
Determination of vitamins A, D, E, and K in human and bovine serum, and ?-carotene and vitamin A palmitate in cosmetic and pharmaceutical products, by isocratic HPLC
Wang LH and Huang SH
Chromatographia, 55(5-6), 289-296 (2002)
Bich Tran et al.
The American journal of clinical nutrition, 99(1), 156-161 (2013-10-11)
Observational data suggested that supplementation with vitamin D could reduce risk of infection, but trial data are inconsistent. We aimed to examine the effect of oral vitamin D supplementation on antibiotic use. We conducted a post hoc analysis of data

Protocolos

Separation of Ergocalciferol (D2), analytical standard; Cholecalciferol (D3), analytical standard

Ascentis Express C18 is suitable for routine analysis of fat-soluble vitamins D2 and D3, providing optimized chromatograms.

Separation of (±)-α-Tocopherol, analytical standard; Menadione (K3), analytical standard; (+)-γ-Tocopherol, analytical standard; Cholecalciferol (D3), analytical standard

Preguntas

1–3 de 3 Preguntas  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 respuesta
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 respuesta
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. I assume the material will be shipped with dry ice. So up to how many days/time the material will remain stable in this shipping condition ?

    1 respuesta
    1. This product is stable for relatively short periods of time. The item is shipped at ambient temperature. A transit time of up to 2 weeks will not impact the quality of this material. Upon delivery, this product should be stored at -20°C.

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