Merck
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PHR1557

Supelco

Methylene Chloride

Pharmaceutical Secondary Standard; Certified Reference Material

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Sinónimos:
Dichloromethane, Methylene chloride
Empirical Formula (Hill Notation):
CH2Cl2
Número de CAS:
75-09-2
Peso molecular:
84.93
Beilstein:
1730800
Número de EC:
200-838-9
Número MDL:
MFCD00000881
ID de la sustancia en PubChem:
329823466
NACRES:
NA.24

Nivel de calidad

300

grado

certified reference material
pharmaceutical secondary standard

Agency

traceable to USP 1601441

densidad de vapor

2.9 (vs air)

presión de vapor

24.45 psi ( 55 °C)
6.83 psi ( 20 °C)

CofA

current certificate can be downloaded

temp. de autoignición

1223 °F

lim. expl.

22 %

envase

ampule of 3x1.2 mL each

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

índice de refracción

n20/D 1.424 (lit.)

bp

39.8-40 °C (lit.)

mp

−97 °C (lit.)

densidad

1.325 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

formato

neat

temp. de almacenamiento

2-30°C

SMILES string

ClCCl

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChI key

YMWUJEATGCHHMB-UHFFFAOYSA-N

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Categorías relacionadas

Descripción general

Methylene chloride, also known as dichloromethane, is an organic solvent with widespread industrial applications.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Methylene Chloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by gas chromatography (GC) technique.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB7796 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictogramas

Exclamation markHealth hazard
GHS07,GHS08

Palabra de señalización

Warning

Frases de peligro

H315 - H319 - H336 - H351

Clasificaciones de peligro

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Central nervous system

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificado de Análisis

Introduzca el número de lote para buscar un certificado de análisis (COA).

Certificado de origen

Introduzca el número de lote para buscar un Certificado de origen (COO).

Más documentos

Pressure-Temperature Nomograph
Structure Search

Quotes and Ordering

Bulk Quote-Order Product
Methylene Chloride
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 5885-5885 (2018)
Accidental intoxication by dichloromethane at work place: Clinical case and literature review
Pacheco C, et al.
Journal of Acute Medicine, 6(2), 43-45 (2016)
K E Mauck et al.
Integrative and comparative biology, 54(2), 193-209 (2014-04-22)
Recent research suggests that plant viruses, and other pathogens, frequently alter host-plant phenotypes in ways that facilitate transmission by arthropod vectors. However, many viruses infect multiple hosts, raising questions about whether these pathogens are capable of inducing transmission-facilitating phenotypes in
Angharad M Roberts et al.
Science translational medicine, 7(270), 270ra6-270ra6 (2015-01-16)
The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an abundant structural, sensory, and signaling filament in muscle) as a common cause of end-stage dilated cardiomyopathy (DCM) promises new prospects for improving heart failure management. However, realization
Guilherme Asmar Alencar et al.
The Journal of clinical endocrinology and metabolism, 99(8), E1501-E1509 (2014-04-09)
Primary macronodular adrenal hyperplasia (PMAH) is a rare cause of Cushing's syndrome, usually characterized by functioning adrenal macronodules and increased cortisol production. Familial clustering of PMAH has been described, suggesting an inherited genetic cause for this condition. The aim of
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