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Merck

230R-1

Caldesmon (E89) Rabbit Monoclonal Primary Antibody

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NACRES:
NA.41
UNSPSC Code:
12352203

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

E89, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (230R-14)
vial of 0.5 mL concentrate (230R-15)
bottle of 1.0 mL predilute (230R-17)
vial of 1.0 mL concentrate (230R-16)
bottle of 7.0 mL predilute (230R-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG

control

appendix, breast

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Quality Level

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Este artículo
231R-1231M-1SAB5500025
clone

E89, monoclonal

clone

EP798Y, monoclonal

clone

CALP, monoclonal

clone

SP226, monoclonal

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human (tested)

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

culture supernatant

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

Analysis Note


IVD

IVD

IVD

RUO

General description

Caldesmon is a regulatory protein that plays a role in smooth muscle contraction with actin, myosin, tropomyosin, and calmodulin. Anti-caldesmon antibody labels smooth muscle and tumors of smooth muscle.[1][2] It also typically shows expression in epithelioid mesothelioma but not in ovarian serous carcinoma.[3][4]

Other Notes

Caldesmon Positive Control Slides, Product No. 230S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: [email protected]

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Markku Miettinen et al.
Archives of pathology & laboratory medicine, 130(10), 1466-1478 (2006-11-09)
Gastrointestinal stromal tumors (GISTs) are specific, generally Kit (CD117)-positive, mesenchymal tumors of the gastrointestinal tract encompassing a majority of tumors previously considered gastrointestinal smooth muscle tumors. They are believed to originate from interstitial cells of Cajal or related stem cells.
W Glenn McCluggage
Advances in anatomic pathology, 11(3), 162-171 (2004-04-21)
In recent years there have been a plethora of publications regarding the value of immunohistochemical studies in diagnosis in gynecological pathology. In many instances, papers are published initially that suggest that a certain antibody or panel of antibodies is of
Camilla E Comin et al.
The American journal of surgical pathology, 30(4), 463-469 (2006-04-21)
Although a large number of immunohistochemical markers that can facilitate the differential diagnosis between epithelioid pleural mesothelioma and lung adenocarcinoma involving the pleura have proven to be valuable, no single antibody has demonstrated absolute sensitivity and/or specificity in making this
K Watanabe et al.
Human pathology, 30(4), 392-396 (1999-04-20)
h-Caldesmon (h-CD) is a protein combined with actin and tropomyosin that regulates cellular contraction. h-CD has been thought to be expressed exclusively in vascular and visceral smooth muscle cells (SMC). We examined h-CD expression immunohistochemically in tumors with SMC and
Camilla E Comin et al.
The American journal of surgical pathology, 31(8), 1139-1148 (2007-08-02)
Distinguishing between epithelioid peritoneal mesothelioma and papillary serous carcinomas involving the peritoneum may be very difficult, owing to overlapping morphologic features. Immunohistochemistry may facilitate establishing a correct diagnosis, but, as no single antibody has demonstrated absolute sensitivity and specificity for

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