This product is not sterile. Stock solutions may be filter sterilized. This material has not been tested for suitability in cell culture. However, this product has been used successfully in cell culture by other researchers. See the link below to review one such example:
https://pmc.ncbi.nlm.nih.gov/articles/PMC2941681/
A6885
Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate
≥98.0% (HPLC), cyclic-AMP-dependent protein kinase (PKA) activator, powder
Sinónimos:
3′,5′-Cyclic AMP sodium salt, cAMP-Na
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
25 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 53,60 € |
100 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 153,00 € |
500 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 226,00 € |
1 g | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 336,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C10H11N5NaO6P · H2O
Número CAS:
Peso molecular:
369.20
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.77
Beilstein/REAXYS Number:
54612
MDL number:
Assay:
≥98.0% (HPLC)
Form:
powder
53,60 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleNombre del producto
Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate, ≥98.0% (HPLC), powder
Quality Segment
assay
≥98.0% (HPLC)
form
powder
color
white
solubility
H2O: 10 mg/mL
storage temp.
−20°C
SMILES string
[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O
InChI
1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
InChI key
BXJBFCKTIWRKMQ-MCDZGGTQSA-M
Application
Adenosine-3′,5′-cyclic monophosphate (cAMP) is an activator of cyclic-AMP-dependent protein kinase A (PKA). The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis. Exogneous cAMP plays a role in the spontaneous activity and contraction of the heart muscle.
Biochem/physiol Actions
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA).
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases and PKA & PKG pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Este artículo | |||
|---|---|---|---|
| description ≥98.0% (HPLC), powder | description ≥97% (HPLC), powder | description ≥98.5% (HPLC), powder | description Cell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. |
| assay ≥98.0% (HPLC) | assay ≥97% (HPLC) | assay ≥98.5% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form solid |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 10 mg/mL | solubility H2O: 100 mg/mL | solubility H2O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.) | solubility water: soluble |
| color white | color white | color white | color white |
Clase de almacenamiento
11 - Combustible Solids
¿Qué está pasando?
WGK 2
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
EPI (equipos de protección individual)
Eyeshields, Gloves, type N95 (US)
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