C3660
Complement C9 from human serum
≥150,000 C9H50 units/mg (using C9 deficient serum)
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Este artículo | C2910 | C2787 | C3535 |
|---|---|---|---|
| biological source human | biological source human | biological source human serum | biological source human |
| assay ≥85% (SDS-GE) | assay ≥85% (SDS-GE) | assay ≥85% (SDS-PAGE) | assay ≥85% (SDS-PAGE) |
| form solution | form solution | form solution | form solution |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Gene Information human ... C9(735) | Gene Information human ... C3(718) | Gene Information human ... C7(730) | Gene Information human ... C8A(731) |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
Aplicación
Complement C9 from human serum is an essential part of the terminal complement system. It has been a topic in cancer research, where extracellular phosphorylation by ecto-PK of K562 cells on serine residues may serve as a protective mechanism against complement in tumor cells. Additionally, it can be used as a biomarker (in fucosylated form) for squamous cell lung cancer, as patients tend to show elevated levels of C9 protein.
Acciones bioquímicas o fisiológicas
Complement component C9 is the final component of the membrane attack complex (MAC) responsible for cell lysis by complement. CD59 binds to both C8 and C9 and prevents assembly of an active MAC, protecting cells against lytic activity.[1]
Forma física
Supplied as a solution in phosphate buffered saline, pH 7.2.
Nota de análisis
Functionally pure by a sensitive hemolytic assay using deficient sera.
Otras notas
View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer
Cláusula de descargo de responsabilidad
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Código de clase de almacenamiento
10 - Combustible liquids
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Yoshimitsu Kuwabara et al.
PloS one, 13(6), e0198472-e0198472 (2018-06-13)
Immunoproteomic analysis was performed to identify unknown, pathology-related molecules in patients with seronegative (SN) obstetric antiphospholipid syndrome (APS) who clinically satisfied the diagnostic criteria for APS, but not the serological criteria. We collected peripheral blood from 13 SN-APS outpatients with
Phosphorylation of the complement component, C9, by an ecto-protein kinase of human leukemic cells
Paasa, Y., et al.
Immunopharmacology and Immunotoxicology, 42, 175-785 (1999)
Y Paas et al.
Archives of biochemistry and biophysics, 316(2), 780-788 (1995-02-01)
Ecto-protein kinases (ecto-PK), primarily of the serine/threonine kinase type, have been previously described on the surface of various normal, transformed, and tumor cells. We have found that in the presence of ATP and Mg2+, exogenously added substrates such as phosvitin
Yuxiang Huang et al.
The Journal of biological chemistry, 281(37), 27398-27404 (2006-07-18)
CD59 is a membrane glycoprotein that regulates formation of the cytolytic membrane attack complex (MAC or C5b-9) on host cell membranes. It functions by binding to C8 (alpha chain) and C9 after their structural rearrangement during MAC assembly. Previous studies
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