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C9972

Cholera Toxin B subunit

Name: Cholera Toxin B subunit
Brand: SIGMA
Price: 241 EUR

mucosal immunogen, lyophilized powder

Oferta disponible

Sinónimos:

CTB

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Talla/SKU	Disponibilidad	Precio
0.5 mg	Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad	241,00 €

Acerca de este artículo

UNSPSC Code:

12352200

PubChem Substance ID:

329775297

NACRES:

NA.77

MDL number:

MFCD02356522

Form:

lyophilized powder

241,00 €

Ahorre hasta 15 %

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Propiedades

Nombre del producto

Cholera Toxin B subunit, biotin conjugate, lyophilized powder

conjugate

biotin conjugate

Quality Segment

200

form

lyophilized powder

mol wt

~12 kDa

composition

Protein, ~40% Lowry

storage temp.

2-8°C

SMILES string

CCOc1ccccc1C(=O)Nc2ccc(Cl)c(c2)C(F)(F)F

InChI

1S/C16H13ClF3NO2/c1-2-23-14-6-4-3-5-11(14)15(22)21-10-7-8-13(17)12(9-10)16(18,19)20/h3-9H,2H2,1H3,(H,21,22)

InChI key

YDXZSNHARVUYNM-UHFFFAOYSA-N

Descripción

General description

Cholera Toxin B (CTB) is secreted by Vibrio cholerae. CTB functions as an oral subunit vaccine for cholera, which is associated with acute watery diarrhoea. It acts as a mucosal immunogen. Cholera toxin (CT) stimulates cell surface molecules, such as antigen presenting cells (APCs), murine and human dendritic cells (DCs). CT also has immunomodulatory properties. It induces the secretion of interleukin 1 (IL-1) from macrophages and enhances their APC function.

Application

Cholera Toxin B subunit has been used:

in immunofluorescence
in the analysis of major histocompatibility complex (MHC) class II lipid raft partitioning
in live cell three-dimensional tracking of SH-SY5Y human neuroblastoma cells
to assess the toll-like receptors (TLR) and FcRγ (Fc receptor γ chain) – CARD9 (caspase recruitment domain family member 9) activation by cholera Toxin B (CTB)

Biochem/physiol Actions

The cholera toxin B subunit is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport.

The cholera toxin B subunit is used for track tracing in neurological research, taking advantage of GM1 ganglioside binding and retrograde transport. Tissue culture cells treated with cholera toxin are not killed and tissues of animals do not become necrotic.

Physical form

Lyophilized powder containing sodium phosphate buffer salts, sodium azide and sodium EDTA.

Analysis Note

Activity measured by ELISA using ganglioside GM₁-coated multiwell plates, rabbit anti-Cholera toxin B subunit, and peroxidase-labeled goat anti-rabbit IgG as the secondary antibody. 50% saturation of binding is achieved with 0.02-1 μg of Cholera toxin B subunit-biotin conjugate per mL. The conjugated B subunit gives a similar value for 50% binding to that of unconjugated B subunit from which it is prepared.

Biotin content ~1.0 mole/mole protein.

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Este artículo	SAE0069	227040	SAB4200844
Sigma-Aldrich C9972 Cholera Toxin B subunit	Sigma-Aldrich SAE0069 Cholera Toxin B subunit	Sigma-Aldrich 227040 Anti-Cholera Toxin, B-Subunit Goat pAb	Sigma-Aldrich SAB4200844 Anti-Cholera toxin, B Subunit (CTxB) antibody, Mouse monoclonal
description biotin conjugate, lyophilized powder	description recombinant, expressed in HEK 293 cells, subunit A free	description lyophilized, Calbiochem^®	description clone CTxB-24, purified from hybridoma cell culture
form lyophilized powder	form lyophilized powder	form lyophilized	form -
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level -
mol wt ~12 kDa	mol wt pentamer observed mol wt ~70 kDa by SDS-PAGE (non-reducing), observed mol wt ~13 & 20 kDa by SDS-PAGE (reducing), calculated mol wt 13 kDa	mol wt -	mol wt -
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
composition Protein, ~40% Lowry	composition -	composition -	composition -
conjugate biotin conjugate	conjugate -	conjugate -	conjugate unconjugated

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Códigos de peligro

H412

Indicaciones de precaución

P273 - P501

Hazard Classifications

Aquatic Chronic 3

Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

EPI (equipos de protección individual)

Eyeshields, Gloves, type N95 (US)

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