E2531
Anti-Erythropoietin antibody produced in rabbit
IgG fraction of antiserum, lyophilized powder
Sinónimos:
Anti-Epo
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Permítanos ayudarleorigen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
IgG fraction of antiserum
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
lyophilized powder
reactividad de especies
human
técnicas
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL
neutralization: suitable
western blot: 1 μg/mL
Nº de acceso UniProt
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... EPO(2056)
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Categorías relacionadas
1 of 4
Este artículo | SAB1410344 | SAB1305804 | SAB1305752 |
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate - | conjugate - |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| antibody form IgG fraction of antiserum | antibody form purified immunoglobulin | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| species reactivity human | species reactivity human | species reactivity human | species reactivity mouse, human |
| technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL, western blot: 1 μg/mL, neutralization: suitable | technique(s) western blot: 1 μg/mL | technique(s) western blot: 1:1000 | technique(s) western blot: 1:1000 |
Descripción general
Epo is mainly produced by liver cells in fetal stages, by kidneys under hypoxic conditions; liver and brain also secrete Epo in less amounts. Anti-Erythropoietin antibody specifically reacts with human Erythropoietin. The EPO gene is mapped to human chromosome 7q22.1.
Inmunógeno
recombinant human erythropoietin expressed in CHO cells.
Aplicación
Anti- Erythropoietin antibody may be used for immunoblotting at a working concentration of 1 μg/mL. For immunohistochemistry, a working concentration of 5-15 μg/mL may be used. The antibody is also suitable for neutralization reactions. Erythropoietin antibody has been used for ELISA in the extracts of leaves of tobacco plant in which recombinant human erythropoietin was expressed. The antibody has also been used for immunoaffinity chromatography to separate the leaf extracts of tobacco expressing recombinant human erythropoietin.
Acciones bioquímicas o fisiológicas
Erythropoietin (Epo) is a pleotropic cytokine that promotes erythropoiesis or proliferation and differentiation of red blood cell precursors. The red blood cell production is stimulated when Epo binds and activates the Epo receptor (EpoR) dimer. EpoR directly regulates the signalling by Jak2, PI3K, NF-κB, STAT5A and STAT5B. Epo also inhibits apoptosis of erythroid progenitors by downregulating Fas (tumor necrosis factor receptor superfamily member 6) and FasL (Fas ligand). [1] The expression of Epo is under the control of the transcription factor hypoxia inducible factor (HIF). Erythropoietin exhibits disease-modifying effects in infectious diseases and chronic inflammatory disorders Anti-Erythropoietin antibody specifically reacts with human Erythropoietin.
Forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Producto relacionado
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Andrew J Conley et al.
Plant biotechnology journal, 7(2), 183-199 (2008-12-06)
Human erythropoietin (EPO) is a pleiotropic cytokine with remarkable tissue-protective activities in addition to its well-established role in red blood cell production. Unfortunately, conventional mammalian cell cultures are unlikely to meet the anticipated market demands for recombinant EPO because of
Amit A Joharapurkar et al.
Current research in pharmacology and drug discovery, 3, 100102-100102 (2022-05-17)
Many anemic chronic kidney disease (CKD) patients are refractory to erythropoietin (EPO) effects due to inflammation, deranged iron utilization, and generation of EPO antibodies. This work assessed the effect of desidustat, an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase
Andrew J Conley et al.
Biotechnology and bioengineering, 103(3), 562-573 (2009-03-07)
The demand for recombinant proteins for medical and industrial use is expanding rapidly and plants are now recognized as an efficient, inexpensive means of production. Although the accumulation of recombinant proteins in transgenic plants can be low, we have previously
Molecular definition of a narrow interval at 7q22. 1 associated with myelodysplasia.
Johnson E J, et al.
Blood, 87(9), 3579-3586 (1996)
Farooqahmed S Kittur et al.
Plant cell reports, 31(7), 1233-1243 (2012-03-01)
Erythropoietin (EPO) is a glycoprotein hormone that displays both hematopoietic and tissue-protective functions by binding to two distinct receptors. Recombinant human EPO (rhuEPO) is widely used for the treatment of anemia, but its use for tissue protection is limited because
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