Merck
All Photos(3)

F4381

Sigma-Aldrich

Furosemide

Synonym(s):
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Empirical Formula (Hill Notation):
C12H11ClN2O5S
CAS Number:
Molecular Weight:
330.74
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

origen biológico

synthetic (organic)

Nivel de calidad

200

ensayo

≥98% (HPLC)

formulario

powder

mp

220 °C (dec.) (lit.)

solubilidad

acetone: 50 mg/mL, clear to slightly hazy, faintly yellow to yellow

emisor

Sanofi Aventis

temp. de almacenamiento

room temp

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Gene Information

Looking for similar products? Visit Product Comparison Guide

Descripción general

Furosemide is a an ototoxic high-ceiling diuretic.

Aplicación

Furosemide has been used:
  • to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
  • to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
  • as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Envase

1, 5, 10, 25 g in glass bottle

Acciones bioquímicas o fisiológicas

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.
Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.
Inhibits ion co-transport in the kidney.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictogramas

Exclamation markHealth hazard

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral - Repr. 1B

Código de clase de almacenamiento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Equipo de protección personal

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service