As provided, every batch of this product released has been tested for solubility in methanol at concentrations up to about 10 mg/mL. It is also known to be soluble in organic solvents, e.g., ethanol (2 mg/mL), DMSO (5 mg/mL), and dimethyl formamide (10 mg/mL). The optimal solvent may vary depending on the specific application.
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F4767
Filipin III from Streptomyces filipinensis
≥85% (HPLC)
Sinónimos:
Filimarisin
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
1 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 146,00 € |
5 mg | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 578,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C35H58O11
Número CAS:
Peso molecular:
654.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
146,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleQuality Segment
assay
≥85% (HPLC)
form
powder
technique(s)
protein detection: suitable
mp
163-180 °C
solubility
methanol: 9.80-10.20 mg/mL, clear, colorless to yellow
antibiotic activity spectrum
fungi, yeast
mode of action
cell membrane | interferes
storage temp.
−20°C
SMILES string
CCCCCC(O)C1C(O)CC(O)CC(O)CC(O)CC(O)CC(O)CC(O)C(C)=C\C=C\C=C\C=C\C=C\C(O)C(C)OC1=O
InChI
1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14-
InChI key
IMQSIXYSKPIGPD-BWJOQPJXSA-N
Application
Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel and immobilized on nitrocellulose membranes.
Filipin has been used in a double staining procedure as a probe for the detection of lipoproteins in polyacrylamide gel and immobilized on nitrocellulose membranes. It is also widely used to localize and quantitate unesterified cholesterol by virtue of a specific fluorescent complex.
Biochem/physiol Actions
Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action may be due to altering membrane permeability and associated functions by binding to membrane sterols. Filipin inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.
Other Notes
Filipin III is the major component of 8 isomeric components in filipin.
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Este artículo | |||
|---|---|---|---|
| description ≥85% (HPLC) | description from Streptomyces filipinensis, 5mg/ml in DMSO based solution | description - | description ≥98% (HPLC), film |
| assay ≥85% (HPLC) | assay ≥90% (HPLC) | assay - | assay ≥98% (HPLC) |
| Quality Level 300 | Quality Level - | Quality Level 300 | Quality Level 300 |
| form powder | form ready-to-use solution | form powder | form film |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility methanol: 9.80-10.20 mg/mL, clear, colorless to yellow | solubility - | solubility - | solubility ethanol: soluble, DMSO: soluble, methanol: soluble, H2O: insoluble |
| mp 163-180 °C | mp - | mp - | mp 288-291 °C |
Palabra de advertencia
Warning
Códigos de peligro
Indicaciones de precaución
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Órganos diana
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
EPI (equipos de protección individual)
dust mask type N95 (US), Eyeshields, Gloves
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Good afternoon; I would be very grateful if you could clarify me which is the best solvent for filipin III (F4767) stock solution preparation. Product specification is different from product information (methanol; ethanol; DMSO..). Thank you in advance.
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