Merck
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M7023

Sigma-Aldrich

Anti-Mouse IgG (whole molecule) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Número MDL:
NACRES:
NA.46

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

IgG fraction of antiserum

antibody product type

secondary antibodies

clon

polyclonal

formulario

buffered aqueous solution

technique(s)

indirect ELISA: 1:80,000
quantitative precipitin assay: 2.0 mg/mL

enviado en

dry ice

temp. de almacenamiento

−20°C

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Descripción general

Immunoglobulin G (IgG) is a member of the immunoglobulin family and contains gamma (γ) heavy chain in the constant (C) region. Monomeric structure of IgG contains two identical heavy chains and two identical light chains with molecular weight of 50kDa and 25kDa respectively. The primary structure of this antibody also contains disulfide bonds implicated in linking the two heavy chains, linking the heavy and light chains and resides inside the chains. IgG is further subdivided into four classes namely, IgG1, IgG2, IgG3 and IgG4 with different heavy chains, named γ1, γ2, γ3 and γ4, respectively.

Especificidad

The antiserum is determined to be immunospecific for mouse IgG by immunoelectrophoresis (IEP) versus normal mouse serum and mouse IgG. By Ouchterlony Double Diffusion (ODD) the product reacts with mouse IgG, mouse IgA and IgM.

Inmunógeno

Anti-Mouse IgG is produced in rabbit using purified mouse IgG as the immunogen. Whole antiserum is purified to provide an IgG fraction of antiserum.

Aplicación

Anti-Mouse IgG (whole molecule) antibody produced in rabbit was used as secondary antibody in immunoblotting, immunoprecipitation and immunohistochemistry.

Acciones bioquímicas o fisiológicas

IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defense of the neonate against infections.

Forma física

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as preservative

Almacenamiento y estabilidad

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

12 - Non Combustible Liquids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificado de Análisis

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Certificado de origen

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Quotes and Ordering

De-Jiang Zhou et al.
Molecular medicine reports, 12(3), 4095-4102 (2015-07-02)
The present study aimed to investigate the antifibrotic effects of juglone on dimethylnitrosamine (DMN)‑induced fibrosis in rats. Juglone, which is a quinone, significantly decreased DMN‑induced rat hepatic fibrosis, which was associated with increased superoxide dismutase (SOD) activity, decreased oxidative stress
J J Li et al.
Cancer research, 59(10), 2340-2346 (1999-05-27)
An estrogen receptor-driven, multistep process for estrogen carcinogenesis in the Syrian hamster kidney is proposed. Because in this species the reproductive and urogenital tracts arise from the same embryonic germinal ridge, it is evident that the kidney has carried over
M R Campanero et al.
Oncogene, 27(9), 1263-1272 (2007-08-29)
The GADD45gamma protein is a potential tumor suppressor whose expression is reduced in several tumors. However, very little is known about the regulation of its expression. We have determined that the most relevant region of its promoter lies between nucleotides
Antibody structure, instability, and formulation.
Wang W, et al.
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
A MacLaren et al.
Oncogene, 19(51), 5906-5918 (2000-12-29)
v-Jun shares the ability of the Myc, E1A, and E2F oncogenes to both sustain cell cycle progression and promote apoptosis in the absence of mitogenic stimulation. To gain an insight into the mechanism of apoptosis sensitization, we examined the possible

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