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P5248

Sigma-Aldrich

Etidronate disodium hydrate

≥97% (NMR), solid

Sinónimos:
Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
Empirical Formula (Hill Notation):
C2H6Na2O7P2 · xH2O
Número de CAS:
Peso molecular:
249.99 (anhydrous basis)
Número de EC:
Número MDL:
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

100

ensayo

≥97% (NMR)

formulario

solid

color

white

mp

>300 °C

solubilidad

H2O: ≥10 mg/mL

temp. de almacenamiento

2-8°C

SMILES string

[Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChI key

GWBBVOVXJZATQQ-UHFFFAOYSA-L

Aplicación

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase. It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).

Envase

10, 100 mg in glass bottle

Acciones bioquímicas o fisiológicas

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.
Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC50 = 80 μM) as compared to the nitrogen containing bisphosphonates

pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

13 - Non Combustible Solids

WGK

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

Certificado de Análisis

Certificado de origen

Synthesis of bisphosphonate derivatives of ATP by T4 RNA ligase
Sillero M A G, et al.
Febs Letters, 580(24), 5723-5727 (2006)
Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes
Griffin S, et al.
Biology of Reproduction (2018)
Etidronate protects chronic ocular hypertension induced retinal oxidative stress and promotes retinal ganglion cells growth through IGF-1 signaling pathway
Su J and Huang M
European Journal of Pharmacology, 841, 75-81 (2018)
Richard Choo et al.
International journal of radiation oncology, biology, physics, 85(5), 1239-1245 (2012-12-26)
Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this
Ping Yin et al.
Journal of agricultural and food chemistry, 60(47), 11664-11674 (2012-11-01)
Novel biosorbent materials obtained from agricultural residues buckwheat hulls (BH) were successfully developed through functionalization with 1-hydroxylethylidenediphosphonic acid (HEDP), and they were characterized. This paper reports the feasibility of using HEDP-BH for removal of heavy metals from stimulated wastewater, the

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