P5248

Etidronate disodium hydrate

≥97% (NMR), solid

• Sinónimos: Dihydrogen (1-hydroxyethylidene)bisphosphonate disodium hydrate
• Fórmula empírica (notación de Hill): C₂H₆Na₂O₇P₂ · xH₂O
• Número CAS: 7414-83-7
• Peso molecular: 249.99 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 329820220
• UNSPSC Code: 12352200
• EC Number: 231-025-7
• MDL number: MFCD00152567

Propiedades

• Nombre del producto: Etidronate disodium hydrate, ≥97% (NMR), solid
• InChI key: GWBBVOVXJZATQQ-UHFFFAOYSA-L
• InChI: 1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
• SMILES string: [Na+].[Na+].CC(O)(P(O)([O-])=O)P(O)([O-])=O
• assay: ≥97% (NMR)
• form: solid
• color: white
• mp: >300 °C
• solubility: H₂O: ≥10 mg/mL
• storage temp.: 2-8°C
• Quality Level: 100

Descripción

Biochem/physiol Actions

Bisphosphonate antiresorptive agent. Less potent inhibitor of farnesyl diphosphate synthase (IC₅₀ = 80 μM) as compared to the nitrogen containing bisphosphonates

Etidronate helps to guard chronic ocular hypertension prompted retinal oxidative stress. It stimulates the development of retinal ganglion cells through insulin-like growth factor 1 (IGF-1) signaling pathway. It may possess neuroprotective effects in in vivo and in vitro rat model of glaucoma. Etidronate belongs to bisphosphonates.[1]

Application

Etidronate disodium hydrate has been used in the synthesis of bisphosphonate derivatives of adenosine triphosphate (ATP)by T4 RNA ligase.[2] It has also been sued to inhibit human farnesyl diphosphate synthase (FDPS).[3]

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves