S1650

Seleno-DL-cystine

Name: Seleno-<SC>DL</SC>-cystine
Brand: SIGMA

>98% (TLC), suitable for HPLC

Sinónimos:

3,3′-diselenobis- alanine,

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Fórmula empírica (notación de Hill):

C₆H₁₂N₂O₄Se₂

Número CAS:

2897-21-4

Peso molecular:

334.09

UNSPSC Code:

12352209

PubChem Substance ID:

24899489

NACRES:

NA.26

MDL number:

MFCD00055925

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Nombre del producto

Seleno-DL-cystine, powder

SMILES string

NC(C[Se][Se]CC(N)C(O)=O)C(O)=O

InChI

1S/C6H12N2O4Se2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)

InChI key

JULROCUWKLNBSN-UHFFFAOYSA-N

assay

>98% (TLC)

form

powder

technique(s)

HPLC: suitable

mp

222 °C

storage temp.

−20°C

Quality Level

200

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Este artículo	A7772	A9627	S0520
Sigma-Aldrich S1650 Seleno-DL-cystine	Sigma-Aldrich A7772 S-(5′-Adenosyl)-L-cysteine	Sigma-Aldrich A9627 Ala-Ala-Ala	Sigma-Aldrich S0520 Selenocystamine dihydrochloride
form powder	form powder	form powder	form powder
technique(s) HPLC: suitable	technique(s) ligand binding assay: suitable	technique(s) -	technique(s) ligand binding assay: suitable
assay >98% (TLC)	assay >98% (TLC)	assay ≥98% (TLC)	assay >98% (TLC)
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
mp 222 °C	mp -	mp -	mp -

pictograms

GHS06,GHS08,GHS09

signalword

Danger

hcodes

H301 + H331,H373,H410

pcodes

P260 - P264 - P273 - P301 + P310 - P304 + P340 + P311 - P314

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Three different systems participate in L-cystine uptake in Bacillus subtilis.

Pierre Burguière et al.

Journal of bacteriology, 186(15), 4875-4884 (2004-07-21)

The symporter YhcL and two ATP binding cassette transporters, YtmJKLMN and YckKJI, were shown to mediate L-cystine uptake in Bacillus subtilis. A triple DeltayhcL DeltaytmJKLMN DeltayckK mutant was unable to grow in the presence of L-cystine and to take up

In vitro radioprotection studies of organoselenium compounds: differences between mono- and diselenides.

B Santhosh Kumar et al.

Radiation and environmental biophysics, 48(4), 379-384 (2009-09-17)

Organoselenium compounds belonging to the class of monoselenides, such as selenomethionine (SeM) and methylselenocysteine (MSeCys) and diselenides including selenocystine (SeCys) and selenopropionic acid (SePA), were examined for their comparative radioprotective effects using in vitro models. Effects of these compounds on

Distribution of Se and its species in Myriophyllum spicatum and Ceratophyllum demersum growing in water containing Se (VI).

Spela Mechora et al.

Chemosphere, 84(11), 1636-1641 (2011-06-28)

The uptake of Se (VI) by two aquatic plants, Myriophyllum spicatum L. and Ceratophyllum demersum L., and its effects on their physiological characteristics have been studied. Plants were cultivated outdoors under semi-controlled conditions and in two concentrations of Na selenate

Nanoparticulate glutathione peroxidase mimics based on selenocystine-pullulan conjugates.

Mamoru Haratake et al.

Bioconjugate chemistry, 19(9), 1831-1839 (2008-08-19)

We synthesized nanoparticulate glutathione peroxidase (GPx) mimics in which selenocystine (SeCyst) was conjugated to a hydrophilic linear polysaccharide, pullulan (Pul). The SeCyst ester-conjugated Pul derivatives (SeCyst-Pul) in phosphate buffer (pH 7) were treated with a sonicator to spontaneously form particulate

Selenocystine induces S-phase arrest and apoptosis in human breast adenocarcinoma MCF-7 cells by modulating ERK and Akt phosphorylation.

Tianfeng Chen et al.

Journal of agricultural and food chemistry, 56(22), 10574-10581 (2008-10-31)

Selenocystine (SeC) is a nutritionally available selenoamino acid with selective anticancer effects on a number of human cancer cell lines. The present study shows that SeC inhibited the proliferation of human breast adenocarcinoma MCF-7 cells in a time- and dose-dependent

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